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2012 Fiscal Year Final Research Report

Investigation of the novel anti-angiogenesis therapy in an orthotopic implantation mouse model of human malignant pleural mesothelioma cells

Research Project

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Project/Area Number 22390166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

SONE Saburo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 客員教授 (40145024)

Co-Investigator(Kenkyū-buntansha) NISHIOKA Yasuhiko  徳島大学, 大学院・ヘスルバイオサイエンス研究部, 教授 (70274199)
HANIBUCHI Masaki  徳島大学, 大学院・ヘスルバイオサイエンス研究部, 准教授 (80335794)
KAKIUCHI Soji  徳島大学, 病院, 講師 (50380100)
GOTO Hisatsugu  徳島大学, 大学院・ヘスルバイオサイエンス研究部, 講師 (00437641)
Project Period (FY) 2010 – 2012
Keywords非閉塞性肺疾患 / 悪性胸膜中皮腫
Research Abstract

The resistance against anti-VEGF therapy was investigated using orthotopic implantation mouse model of human malignant pleural mesothelioma cells. Although tumor angiogenesis was inhibited in the early phase ofanti-VEGF therapy, microvessel density was turned to increase in the late phase ofthe therapy, suggesting that the tumor acquired the resistance against anti-VEGF therapy. We found that the host FGF2 was up-regulated in the resistant tumor, and anti-FGFR therapy in combination with anti-VEGF therapy was more effective compared to anti-VEGF therapy alone. Angiogenic switch into different factors such as FGF2 seemed to play important role in the resistance against anti-VEGF therapy.

  • Research Products

    (22 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Book (4 results)

  • [Journal Article] Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironme2013

    • Author(s)
      Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S
    • Journal Title

      Clin Exp Metastasis

      Volume: 30 Pages: 333-344

    • DOI

      DOI:10.1007/s10585-012-9540-y

    • Peer Reviewed
  • [Journal Article] imeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity2013

    • Author(s)
      Kaneko MK, Kunita A, Abe S, Tsujimoto Y, Fukayama M, Goto K, Sawa Y, Nishioka Y, Kato Y
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 1913-1919

    • DOI

      DOI:10.1111/j.1349-7006.2012.02385.x

    • Peer Reviewed
  • [Journal Article] an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity2012

    • Author(s)
      Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Saijo A, Kakiuchi S, Maekawa Y, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
    • Journal Title

      Mol Cancer Ther

      Volume: 11 Pages: 2578-2587

    • DOI

      DOI:10.1158/1535-7163.MCT-12-0640

    • Peer Reviewed
  • [Journal Article] Malignant pleural effusion: further translational research is crucia2012

    • Author(s)
      Nishioka Y
    • Journal Title

      Transl Lung Cancer Res

      Volume: 1 Pages: 167-169

    • DOI

      DOI:10.1111/j.1349-7006.2012.02385.x.

    • Peer Reviewed
  • [Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells2012

    • Author(s)
      Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 895-902

    • DOI

      DOI:10.3892/or.2012.1887.

    • Peer Reviewed
  • [Journal Article] Dual inhibition of met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer2012

    • Author(s)
      Takeuchi S, Wang W, Li Q, Yamada T, Kita K, Donev IS, Nakamura T, Matsumoto K, Shimizu E, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano
    • Journal Title

      Am J Pathol

      Volume: 181 Pages: 1034-1043

    • DOI

      DOI:10.1016/j.ajpath.2012.05.023.

    • Peer Reviewed
  • [Journal Article] a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model2012

    • Author(s)
      Van TT, Hanibuchi M, Goto H, Kuramoto T, Yukishige S, Kakiuchi S, Sato S, Sakaguchi S, Dat LT, Nishioka Y, Akiyama SI, Sone S, SU666
    • Journal Title

      Respirology

      Volume: 17 Pages: 984-990

    • DOI

      DOI:10.1111/j.1440-1843.2012.02193.x.

    • Peer Reviewed
  • [Journal Article] 呼吸器疾患におけるトランスレーショナルリサーチ:現状と将来展望2012

    • Author(s)
      西岡安彦, 曽根三郎
    • Journal Title

      呼吸器内科

      Volume: 21 Pages: 483-484

    • URL

      http://www.kahyo.com/item/KO201206-216

    • Peer Reviewed
  • [Journal Article] Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile nalysis of non-small cell lung cancer in mic2012

    • Author(s)
      Dat LT, Matsuo T, Yoshimaru T, Kakiuchi S, Goto H, Hanibuchi M, Kuramoto T, Nishioka Y, Sone S, Katagiri T
    • Journal Title

      Int J Oncol

      Volume: 40 Pages: 1455-1469

    • DOI

      DOI:10.3892/ijo.2012.1348

    • Peer Reviewed
  • [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression2012

    • Author(s)
      abr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Mori
    • Journal Title

      Clin Exp Metastasis

      Volume: 29 Pages: 207-216

    • DOI

      DOI:10.1007/s10585-011-9443-3.

    • Peer Reviewed
  • [Journal Article] Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cance2012

    • Author(s)
      Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano S
    • Journal Title

      Clin Cancer Res

      Volume: 18 Pages: 1663-1671

    • DOI

      DOI:10.1158/1078-0432.CCR-11-1171.

    • Peer Reviewed
  • [Journal Article] Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells2011

    • Author(s)
      Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 2157-2163

    • DOI

      DOI:10.1111/j.1349-7006.2011.02093.x.

    • Peer Reviewed
  • [Journal Article] Pleural mesothelioma instigates tumor- associated fibroblasts to promote progression via a malignant cytokine network2011

    • Author(s)
      Li Q, Wang W, Yamada T, Matsumoto K, Sakai K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yasumoto K, Yano S
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 1483-1493

    • DOI

      DOI:10.1016/j.ajpath.2011.05.060.

    • Peer Reviewed
  • [Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice2011

    • Author(s)
      Van TT, Hanibuchi M, Kakiuchi S, Sato S, Kuramoto T, Goto H, Mitsuhashi A, Nishioka Y, Akiyama S, Sone S
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 68 Pages: 497-504

    • DOI

      DOI:10.1007/s00280-010-1503-x

    • Peer Reviewed
  • [Journal Article] E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor recepto2011

    • Author(s)
      Ogino H, Hanibuchi M, Kakiuchi S, Trung VT, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S
    • Journal Title

      Mol Cancer The

      Volume: 10 Pages: 1218-1228

    • DOI

      DOI:10.1158/1535-7163.MCT-10-0707.

    • Peer Reviewed
  • [Journal Article] Role of tyrosine kinase inhibitors in tumor immunology2011

    • Author(s)
      Nishioka Y, Aono Y, Sone S
    • Journal Title

      Immunotherapy

      Volume: 3 Pages: 107-116

    • DOI

      DOI:10.2217/imt.10.79

    • Peer Reviewed
  • [Journal Article] ntiangiogenic therapies for malignant pleural mesothelioma2011

    • Author(s)
      Yano S, Li Q, Wang W, Yamada T, Takeuchi S, Nakataki E, Ogino H, Goto H, Nishioka Y, Sone S
    • Journal Title

      Front Biosci

      Volume: 16 Pages: 740-748

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/21196199.

  • [Journal Article] Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice2010

    • Author(s)
      Sakaguchi S, Goto H, Hanibuchi M, Otsuka S, Ogino H, Kakiuchi S, Uehara H, Yano S, Nishioka Y, Sone, S
    • Journal Title

      Clin Exp Metastasis

      Volume: 27 Pages: 351-359

    • DOI

      DOI:10.1007/s10585-010-9333-0

    • Peer Reviewed
  • [Book] 学研メディカル秀潤社、がん転移:臨床と研究の羅針盤2010

    • Author(s)
      曽根三郎
    • Total Pages
      58-62
  • [Book] 疾患と治療薬改訂第6版-医師・薬剤師の為のマニュアル2010

    • Author(s)
      曽根三郎
    • Total Pages
      132-136
    • Publisher
      南江堂
  • [Book] 今日の診断指針第6 版2010

    • Author(s)
      曽根三郎
    • Total Pages
      315-322
    • Publisher
      医学書院
  • [Book] 呼吸器疾患最新の治療2010

    • Author(s)
      矢野聖二
    • Total Pages
      432-434
    • Publisher
      南江堂

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Published: 2014-08-29  

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