2012 Fiscal Year Final Research Report
Elucidation of the role of TDP-43 in microRNA biogenesis and ALS pathogenesis
| Project/Area Number |
22390176
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
KAWAHARA Yukio 大阪大学, 大学院・医学系研究科, 特任准教授 (常勤) (80542563)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経分子病態学 / ALS / RNA / 神経変性疾患 |
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| Research Abstract |
TDP-43 is a RNA binding protein and associated with the pathogenesis of ALS. However, the physiological functions of TDP-43, especially related to the disease pathogenesis are not fully understood. In this study, we show that TDP-43 facilitates the production of a subset of pre-miRNAs by both interacting with the Drosha complex and binding directly to the relevant pri-miRNAs. Furthermore, cytoplasmic TDP-43, which interacts with the Dicer complex, promotes the processing of some of these pre-miRNAs. Finally, we show that involvement of TDP-43 in miRNA biogenesis is indispensable for neuronal outgrowth. These results support a previously uncharacterized role for TDP-43 in post-transcriptional regulation of miRNA expression.
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[Journal Article] A Subset of Circulating MicroRNAs are Predictive for Cardiac Death After Discharge for Acute Myocardial Infarction2012
Author(s)
Matsumoto S, Sakata Y, Nakatani D, Suna S, Mizuno H, Shimizu M, Usami M, Sasaki T, Sato H, Kawahara Y, Hamasaki T, Nanto S, Hori M and Komuro I
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 427(2)
Pages: 280-284
Peer Reviewed
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