2012 Fiscal Year Final Research Report
Comprehensive determination and functional analysis of novel peptides in the hypothalamus
| Project/Area Number |
22390190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Hideki 宮崎大学, 医学部, 講師 (10305097)
UENO Hiroaki 宮崎大学, 医学部, 助教 (00381062)
TOSHINAI Koji 宮崎大学, 医学部, 講師 (80381101)
TSUCHIMOCHI Wakaba 宮崎大学, 医学部, 医員 (90573303)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 摂食調節 / 視床下部 / ペプチド / 細胞内情報伝達 / エネルギー代謝 |
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| Research Abstract |
The main function of the hypothalamus is homeostasis, or maintaining the body’s status. Discovering novel bioactive peptides and their functions are an important role to elucidate unknown biological function and drug discovery. We discovered novel peptides in the hypothalamus by our newly developed comprehensive analyses, and from that discovery we clarified the new system of biological regulation.
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[Journal Article] Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro2012
Author(s)
Moin AS, Yamaguchi H, Rhee M, Kim JW, Toshinai K, Waise TM, Naznin F, Matsuo T, Sasaki K, Minamino N, Yoon KH, Nakazato M
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Journal Title
Biochem Biophys Res Commun
Volume: 428
Pages: 512-517
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[Journal Article] an anorectic peptide regulated by leptin and metabolic state2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.: Neuropeptide W
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, and Minamino N
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Journal Title
J Neurochem
Volume: 114
Pages: 1097-1106
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