2012 Fiscal Year Final Research Report
Evaluation system for regenerative medicine of genetic disorders by using cloned pigs established from endoderm somatic stem cells
| Project/Area Number |
22390209
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kumamoto University |
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Principal Investigator |
ENDO Fumio 熊本大学, 大学院・生命科学研究部, 教授 (00176801)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kimitoshi 熊本大学, 医学部附属病院, 講師 (30336234)
MATSUMOTO Shiro 熊本大学, 医学部附属病院, 助教 (70467992)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 再生医学 / 移植・再生医療 / 糖尿病 / 発生・分化 / バイオテクノロジー |
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| Research Abstract |
We first isolated tissue stem cells originated from porcinesalivary gland. This clone was used for the generation of cloned pigs. Using this clonedpigs, we established a model system of cell-transplantation for the treatment of liverand pancreatic disorders. We also established a new culture system using variousconcentrations of amino acids in the medium.
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[Journal Article] Calreticulin induces dilatedcardiomyopathy2013
Author(s)
Lee D, Oka T, Hunter B, Robinson A, PappS, Nakamura K, Srisakuldee W, Nickel BE,Light PE, Dyck JRB, Lopaschuk GD,Kardami E, Opas M, and Michalak M
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Journal Title
Plos One
Volume: (inpress)
Peer Reviewed
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[Journal Article] p.E66Q Mutation in the GLAGene is Associated with a High Risk ofCerebral Small-Vessel Occlusion inElderly Japanese Males2013
Author(s)
Nakamura K, Sekijima Y, NakamuraK,Hattori K, Nagamatsu K, Shimizu Y,Yazaki M, Sakurai A, Endo F, FukushimaY, Ikeda S
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Journal Title
Eur J Neurol
Volume: (inpress)
Peer Reviewed
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[Journal Article] Re-evaluation of the indications forliver transplantation in Wilson'sdisease based on the outcomes ofpatients referred to a transplantcenter2013
Author(s)
Ohya Y, Okajima H, Honda M, HayashidaS, Suda H, Matsumoto S, Lee KJ,Yamamoto H, Takeichi T, Mitsubuchi H,Asonuma K, Endo F, Inomata Y
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Journal Title
Pediatr Transplant
Volume: 17(4)
Pages: 369-737
Peer Reviewed
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[Journal Article] Current status of hepaticglycogen storage disease in Japan:clinical manifestations, treatmentsand long-term outcomes2013
Author(s)
Kido J, Nakamura K, Matsumoto S,Mitsubuchi H, Ohura T, Shigematsu Y,Yorifuji T, Kasahara M, Horikawa R,Endo F
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Journal Title
J Hum Genet
Volume: 58(5)
Pages: 285-92
Peer Reviewed
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