Investigation of the brain and cell injury responsible for depression with immune-challenged animal model

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390226
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187)
• Co-Investigator(Renkei-kenkyūsha): ONITSUKA Toshiaki 九州大学, 病院, 講師 (00398059) ; MOTOMURA Keisuke 九州大学, 病院, 助教 (60432944) ; MIURA Tomofumi 九州大学, 大学院・医学研究院, 助 (90404053)
• Project Period (FY): 2010 – 2012
• Keywords: うつ病 / サイトカイン / 精神疾患 / 神経科学 / 脳

Research Abstract

By systemic injection of bacterial endotoxin into mice, we generated an animal model of depression which showed depressive behavior and microglial activation in the regions around the periventricular organs. In another experiment on forced swim test, some

Research Products

• [Journal Article] Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalyticapproach (2013)
  • Author(s): Kato TA, Kanba S
  • Journal Title: Front Hum Neurosci. Volume: 7 Pages: 13
  • DOI: DOI:10.3389/fnhum.2013.00013
• [Journal Article] Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: An ERP study (2013)
  • Author(s): Oribe N, Hirano Y, Kanba S, Del Re EC, Seidman LJ, Mesholam-Gately R, Spencer KM. McCarley RW, Niznikiewicz MA
  • Journal Title: Schizophr Res.
  • DOI: DOI:pii:S0920-9964(13)00053-4.10.1016/j.schres.2013.01.015.
• [Journal Article] Mechanism forretardation of amyloid fibril formation by sugars in Va,6 protein. (2013)
  • Author(s): Abe M, Abe Y, Ohkuri T, Mishima T, Monji A, Kanba S, Ueda T.
  • Journal Title: Protein Sci.
  • DOI: DOI:10.1002/pro.2228.
• [Journal Article] Lost in translation: confusion about depression andantidepressant therapy in Japan (2013)
  • Author(s): Motomura K, Kanba S
  • Journal Title: Psychiatry Clin Neurosci. Volume: 67(1) Pages: 1-2
  • DOI: DOI:10.1111/pcn.12011.
• [Journal Article] A Population-Specific Uncommon Variant in GRIN3A Associated with Schizophrenia. (2013)
  • Author(s): Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, YamadaK, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
  • Journal Title: Biol Psychiatry. Volume: 73(6) Pages: 532-9
  • DOI: DOI:10.1016/j.biopsych.2012.10.024.
• [Journal Article] Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors. (2012)
  • Author(s): Kato TA, Watabe M, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsurni H, Kanba S.
  • Journal Title: PLoS One Volume: 7(7) Pages: e40461
• [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients. (2012)
  • Author(s): Oda Y, *Onitsuka T, Tsuchimoto R, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Miura T, Kanba S.
  • Journal Title: PLoS One Volume: 7(7) Pages: e39955
• [Journal Article] Altered face inversion effect and association betweenface N170 reduction and social dysfunction in patients with schizophrenia. (2012)
  • Author(s): Tsunoda T,_Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, *Onitsuka T.
  • Journal Title: Clin Neurophysiol. Volume: 123(9) Pages: 1762-8
• [Journal Article] Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction? (2012)
  • Author(s): Watabe M, Kato TA, Monji A, Horikawa H, Kanba S.
  • Journal Title: Psychopharmacology (Berl). Volume: 220(3) Pages: 551-7
• [Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia. (2011)
  • Author(s): Kato TA, Monji A, Yasukawa K, Mizouchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, *Kanba S
  • Journal Title: Schizophr Res Volume: 29(2-3) Pages: 172-82
• [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia (2011)
  • Author(s): Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Miura T, *Onitsuka T.
  • Journal Title: Schizophr Res Volume: 33(1-3) Pages: 99-105
• [Journal Article] Inhibitory effects of SSRIs on IFN-y induced microglial activation through the regulation of intracellular calcium (2010)
  • Author(s): Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, *Kanba S.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 34(7) Pages: 1306-16
• [Presentation] Genomic and clinical phenotype considerations in evaluating antidepressant-induced mania to individualize the treatment for bipolar depression (2012)
  • Author(s): Fry M A and Kanba S
  • Organizer: symposium chair 5th Biennial Conference of the International Society For Bipolar Disorders
  • Place of Presentation: Instanbul, Turkey
  • Year and Date: 20120300
• [Presentation] Neuroinflammatory hypothesis of schizophrenia (2012)
  • Author(s): Kanba S
  • Organizer: Taiwanese Society of Biological Psychiatry and Neuropsychopharmacology 2012
  • Year and Date: 20120000
• [Presentation] Depression In Asia, symposium Characteristics of depression in young Japanese. (2012)
  • Author(s): Kanba S
  • Organizer: 15th Pacific Rim College of Psychiatrists Scientific Meeting 2012
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-10-27
• [Presentation] Czech Plenary lecture Neuroinflammatory hypothesis of schizophrenia (2012)
  • Author(s): Kanba S
  • Organizer: World Psychiatric Association International Congress 2012 Prague
  • Year and Date: 2012-10-20
• [Presentation] WPA regional symposium in Kaoshung (2011)
  • Author(s): Kanba S
  • Organizer: symposium speaker Depression in Asia
  • Year and Date: 20111100
• [Presentation] Antidepressant effects in the forced swim test. (2011)
  • Author(s): Yanagida S et al.
  • Organizer: 8th IBRO World Congress of neuroscience
  • Place of Presentation: Florence, Italy.
  • Year and Date: 20110714-18
• [Presentation] Neuroinflammatory pathology in schizophrenia and depression: From diagnosisito treatment. (2011)
  • Author(s): Kanba, S and Muller N
  • Organizer: 10th WFSBP Prague, symposium chairman
  • Year and Date: 20110500
• [Presentation] Systemic lipopolysaccharaide induces prolonged microglial activation in specific brain regions in mice. (2011)
  • Author(s): Ohashi A et al.
  • Organizer: Asian College of Neuropyschopharamacology.
  • Place of Presentation: Asian College of Neuropyschopharamacology.
  • Year and Date: 2011-09-23
• [Presentation] Innovations in themanagement of bipolar disorder (2010)
  • Author(s): Kanba, S
  • Organizer: CINP Hong Kong, symposium
  • Year and Date: 20100600
• [Presentation] Controversies and New Treatment of Diabetes (2010)
  • Author(s): Kanba, S
  • Organizer: 8th International Diabetes Federation; Western Pacific Region Congress Prevalence of depression in metabolic syndrome: the Hisayama Study
  • Place of Presentation: Busan
  • Year and Date: 2010-10-18
• [Book] 成人精神医療からみた創発OCDの特徴子どもの強迫性障害:診断・治療ガイドライン (2012)
  • Author(s): 樋口麻衣子、中尾智博、神庭重信、斎藤万比古、金生由紀子
  • Total Pages: 268-274
  • Publisher: 星和書店
• [Book] 現代精神医学事典 (2011)
  • Author(s): 加藤敏、神庭重信、中谷陽二、武田雅俊、狩野力八郎、市川宏伸
  • Publisher: 弘文堂
• [Book] 「うつ」の構造 (2011)
  • Author(s): 神庭重信、内海健
  • Publisher: 弘文堂
• [Book] 脳科学エッセンシャル、精神疾患の生物学的理解のために (2010)
  • Author(s): 神庭重信、加藤忠史
  • Publisher: 中山書店