2012 Fiscal Year Final Research Report
Development of a total microreactor system for radiosynthesis of^<18>F-labeled PET probes
| Project/Area Number |
22390228
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
IWATA Ren 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
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| Co-Investigator(Kenkyū-buntansha) |
FURUMOTO Shozo 東北大学, 大学院・医学系研究科, 准教授 (00375198)
TAKAHASHI Kazuhiro 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー (20370257)
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| Co-Investigator(Renkei-kenkyūsha) |
OZEKI Eiichi 島津製作所, 基盤技術研究所, 主幹研究員 (30192529)
SAIKI Hidekazu 島津製作所, 基盤技術研究所, 主任 (70466382)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子イメージング / マイクロリアクター / 標識合成 / PET / 標識プローブ |
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| Research Abstract |
In order to utilize electrochemically concentrated [^<18>F]fluoride in microreactor radiosynthesis of ^<18>F-labeled probes, we developed a total system for carrying out the whole procedures from separation of [^<18>F]fluoride to purification of a ^<18>F-labeled probe based on the following techniques: to improve the concentration of [^<18>F]fluoride with a newly designed chip; to develop a new evaporation chip for on-line concentration of a reaction product solution; to develop a rapid, efficient method for purifying a final product with a solid phase extraction column. We demonstrated that the decrease in concentration of [^<18>F]fluoride in acetonitrile was mainly caused by diffusion in transfer tubing and that the evaporation chip worked efficiently under optimized conditions.
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[Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using[^<11>C]BF-2272011
Author(s)
Kaneta T., Okamura N.,Minoshima S., Furukawa K., Tashiro M., Furumoto S., Iwata R., Fukuda H., Takahashi S., Yanai K., Kudo Y., Arai H.
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Journal Title
Ann. Nucl. Med
Volume: 25
Pages: 732-739
DOI
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with glioma by using positron emission tomography with 1-(2-[^<18>F]fluoro-1-[hydrohymethyl]ethoxy)-methyl-2- nitroimidazole, a new ^<18>F-labeled2-nitroimidazole analog2010
Author(s)
Shibahara I., Kumabe T., KanamoriM., Saito R., Sonoda Y., Watanabe M., Iwata R., Higano S., Takanami K., Takai Y., Tominaga T.
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Journal Title
J. Neurosurg
Volume: 11
Pages: 358-368
DOI
Peer Reviewed
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