2012 Fiscal Year Final Research Report
Functional molecular imaging studies by rapid EPR imaging method
| Project/Area Number |
22390236
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJII Hirotada 札幌医科大学, 医療人育成センター, 教授 (70209013)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRATA Hiroshi 北海道大学, 大学院・情報科学研究科, 教授 (60250958)
ITOH Kouichi 徳島文理大学, 薬学部, 教授 (30291149)
NAGASAKI Yukio 筑波大学, 数理物質科学研究所, 教授 (90198309)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 電子常磁性共鳴 / イメージング / ESR / EPR / 酸化ストレス / 活性酸素 |
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| Research Abstract |
Electron paramagnetic resonance (EPR) imaging using nitroxides is a powerful, noninvasive method for visualizing the redox status modulated by oxidative stress in vivo. However, to date, it has not always been possible to obtain three-dimensional (3D) images with a continuous wave (CW)-EPR imager in small rodents while using nitroxides. Due to improvements in imagers that enable rapid data-acquisition, the feasibility of 3D EPR imaging with good quality in mice was tested with nitroxides of different lipophilicities. The improved CW-EPR imager may be a useful noninvasive tool for assessing changes in the redox status of living subjects under oxidative stress.
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