Elucidation and conquest of the radioresistant for the patients with advanced cervical cancer using the molecular technique

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390237
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kansai Medical University
• Principal Investigator: HARIMA Yoko 関西医科大学, 医学部, 准教授 (80140276)
• Co-Investigator(Renkei-kenkyūsha): NAKANO Takashi 群馬大学, 大学院・医学系研究科, 教授 (20211427) ; ONO Tatsuya 群馬大学, 重粒子線医学推進機構, 教授 (10344061) ; TOITA Takafumi 琉球大学, 医学部, 准教授 (30237036) ; IKUSHIMA Hitoshi 徳島大学, 医学部・歯学部附属病院, 教授 (90202861) ; TOKUMARU Sunao 佐賀大学, 医学部, 教授 (90304899) ; KANEYASU Yuko 広島大学, 医歯(薬)学総合研究科, 助教 (90204586) ; IKEDA Koshi 関西医科大学, 医学部, 講師 (80288802) ; UTSUNOMIYA Keita 関西医科大学, 医学部, 講師 (20193914)
• Project Period (FY): 2010 – 2012
• Keywords: 子宮頸癌 / 放射線抵抗性 / 予後因子 / バイオマーカー

Research Abstract

In our previous study, we identified apolipoprotein C-II (ApoC-II) using the cervical cancer patient blood in predicting the radiation treatment outcome. This study is a multi-Institutional prospective study of ApoC-II. In addition, we divided it into two group good-prognosis, and poor-prognosis, using a cancer tissue and examined miRNA. In the good-prognosis group, miR-200a, miR-200b* and miR-452 were significantly overexpressed. On the other hand, miR-484 and hcmv-miR-UL70-3p were significantlyoverexpressed in the poor-prognosis group.

Research Products

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• [Journal Article] Cervical Cancer (Vulva Cancer)Committee of Japanese GynecologicOncology Group (JGOG). Phase II studyof concurrent chemoradiotherapy withhigh-dose-rate intracavitarybrachytherapy in patients withlocally advanced uterine cervicalcancer: efficacy and toxicity of a lowcumulative radiation dose schedule. (2012)
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• [Journal Article] Concurrent chemoradiotherapy withpaclitaxel and cisplatin foradenocarcinoma of the cervix. (2012)
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• [Journal Article] Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG). (2012)
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• [Journal Article] Treatment0utcome of medium-dose-rateintracavitary brachytherapy forcarcinoma of the uterine cervix:comparison with low-dose-rateintracavitary brachytherapy. (2012)
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• [Journal Article] AnInvestigation of the Early Detectionof Radiation Induced Apoptosis by99mTc-Annexin V and201Thallium-Chloride in a Lung CancerCell Lin. (2012)
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• [Journal Article] ApoC-IIキットによる子宮頸がんの放射線治療効果予測. (2011)
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• [Journal Article] MK615,a prospective anti-proliferativeagent, enhances CD4/CD8 ratio after exposure to irradiation (2011)
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• [Journal Article] Intracavitary Combined with CT-guidedInterstitial Brachytherapy forLocally Advanced Uterine CervicalCancer: Introduction of the Techniqueand a Case Presentation. (2011)
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• [Journal Article] Expressionof hypoxia-inducible factor 1αpredicts clinical outcome afterpreoperativehyperthermo-chemoradiotherapy forlocally advanced rectal cancer. (2011)
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• [Journal Article] Blood flow change quantification incervical cancer before and afterradiation therapy using perfusion CT (2011)
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• [Journal Article] Changing trend in thepatterns of pretreatment diagnosticassessment for patients with cervicalcancer in Japan (2011)
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• [Journal Article] Hiraoka M; JCOG Radiation TherapyStudy Group. A consensus-basedguideline defining clinical targetvolume for primary disease in externalbeam radiotherapy for intact uterinecervical cancer (2011)
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• [Journal Article] High-risk group for locoregionalrecurrence in patients with stageIB-IIB squamous cell carcinoma of thecervix treated with concurrentchemoradiotherapy. (2011)
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• [Journal Article] Disease Committee ofRadiation Oncology, Japanese Gynecologic Oncology Group. Radiotherapy quality assurance of the Japanese Gynecologic Oncology Group study (JGOG1066): a cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer. (2011)
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• [Journal Article] A consensus-basedguideline defining clinical targetvolume for primary disease in externalbeam radiotherapy for intact uterinecervical cancer. JCOG RadiationTherapy Study Group. (2011)
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• [Journal Article] Carbon ion radiotherapy atthe Gunma University Heavy Ion MedicalCenter: New facility set-up. (2011)
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• [Journal Article] Expression of hypoxia-induciblefactor 1.FNa predicts clinicaloutcome after preoperativehyperthermo-chemoradiotherapy forlocally advanced rectal cancer. (2011)
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• [Journal Article] Genetic variants ofNPAT-ATM and AURKA are associated withan early adverse reaction in thegastrointestinal tract of patientswith cervical cancer treated withpelvic radiation therapy. (2011)
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• [Journal Article] High-dose-rate interstitialbrachytherapy with computedtomography-based treatment planningfor patients with locally advanceduterine cervical carcinoma. (2011)
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• [Journal Article] Dose volume analysis ofradiotherapy for inoperable patientswith stage I-II endometrialcarcinoma. (2011)
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• [Journal Article] Genetic Variants of NPAT-ATM and AURKA are associated with an Early Adverse Reaction in the Gastrointestinal Tract of patients with cervical cancer treated with pelvic radiation therapy. (2011)
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• [Journal Article] Carbon ion radiotherapy at GunmaUniversity: currently indicatedcancer and estimation of need (2011)
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• [Journal Article] 子宮頚癌に対する放射線治療 (2011)
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• [Journal Article] JROSG(JapaneseRadiation Oncology Study Group)の現状- (2011)
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• [Journal Article] High-dose-rateIntracavitary Brachytherapy Combinedwith External Beam Radiotherapy forStage IIIb Adenocarcinoma of theUterine Cervix in Japan: AMulti-Institutional Study of JapaneseSociety of Therapeutic Radiology andOncology 2006-2007 (Study of JASTRO2006-2007) (2010)
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• [Journal Article] 進行期子宮頸癌の放射線治療後予後不良に関与するTTK遺伝子 (2010)
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• [Journal Article] Current Advancement inRadiation Therapy for UterineCervical Cancer. (2010)
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• [Journal Article] CT-based 3D dose-volume parameter ofthe rectum and late rectalcomplication in patients withcervical cancer treated withhigh-dose-rate intracavitarybrachytherapy. (2010)
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• [Journal Article] Change in fibroblast growth factor2 expression as an early phaseradiotherapy-responsive marker insequential biopsy samples frompatients with cervical cancer duringfractionated radiotherapy. (2010)
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• [Journal Article] Aconsensus-based guideline on clinicaltarget volume (CTV) for pelvic lymphnodes in external beam radiotherapyfor uterine cervical cancer. (2010)
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• [Journal Article] JROSG workingsubgrouo of gastroentestinal cancerPostoperative external beamradiotherapy for resected pancreaticadenocarcinoma: impact ofchemotherapy on local control andsurvival. (2010)
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• [Presentation] miRNAを指標とした子宮頸癌IIIB期の抗癌剤併用放射線治療予後予測 (2012)
  • Author(s): 播磨洋子
  • Organizer: 第25回日本放射線腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-24
• [Presentation] Apolipoprotein C-II is a potential serum biomarker as a prognostic factor of patients with locally advanced cervical cancer after chemoradiotherapy. (2012)
  • Author(s): Yoko Harima
  • Organizer: 54th Annual Meeting of American Society for Radiation Oncology.
  • Place of Presentation: ボス トン(アメリカ)
  • Year and Date: 2012-10-28
• [Presentation] Prediction of outcome for the patients with advanced cervical cancers after chemoradiotherapy using miRNA analysis (2012)
  • Author(s): 播磨洋子
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] The combination therapy of hyperthermia, radiotherapy, and/orchemotherapy in the past, present, and future direction for advanced cervical cancer. (2012)
  • Author(s): Yoko Harima
  • Organizer: 11th Annual Meeting of International Congress of Hyperthermic Oncology.
  • Place of Presentation: 京都
  • Year and Date: 2012-08-28
• [Presentation] miRNAを指標とした子宮頸癌IIIB期の抗癌剤併用放射線治療予後予測因子検索第41回放射線による制癌シンポジウム (2012)
  • Author(s): 播磨洋子
  • Organizer: 第50回日本放射線腫瘍学会生物部会学術大会
  • Place of Presentation: 沖縄宜野湾市
  • Year and Date: 2012-06-30
• [Presentation] miRNA解析を用いたIIIB期子宮頸癌の抗癌剤併用放射線治療後の予後因子 (2012)
  • Author(s): 播磨洋子
  • Organizer: 第71回日本医学放射線学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-15
• [Presentation] Apolipoprotein C-IIcorrelated with outcome of patientswith locally advanced cervical cancerafter chemoradiotherapy. (2011)
  • Author(s): Yoko Harima
  • Organizer: 97th AnnualMeeting of Radiological Society ofNorth America
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2011-11-28
• [Presentation] The efficacy of irradiation on multidrug resistance(MDR) in non-small cell cancer. (2011)
  • Author(s): Keita Utsunomiya
  • Organizer: 97thAnnual Meeting of Radiological Societyof North America
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2011-11-28
• [Presentation] 局所進行期子宮頸癌の放射線治療予後予測因子としてのHIF1A遺伝子 (2011)
  • Author(s): 播磨洋子
  • Organizer: 第24回日本放射線腫瘍学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-11-19
• [Presentation] Prediction of outcome for the patients with Stage IIIB cervicalcancers after chemoradiotherapy usingmiRNA microarray analysis (2011)
  • Author(s): 播磨洋子
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-11-04
• [Presentation] IIIB・IVA期子宮頸癌の放射線治療予後予測因子としてのPLAU、HIF1A遺伝子 (2011)
  • Author(s): 播磨洋子
  • Organizer: 第70回日本癌治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-29
• [Presentation] 進行期子宮頸癌の放射線治療予 後予測バイオマーカーとしてのアポリポ蛋白C-II (2011)
  • Author(s): 播磨洋子
  • Organizer: 第70回日本医学放射線学会総会
  • Place of Presentation: Web公開
  • Year and Date: 2011-05-20
• [Presentation] Apolipoprotein C-II as a potential biomarker and prognostic factor for locally advanced cervicalcancer after radiotherapy. (2011)
  • Author(s): Yoko Harima
  • Organizer: ESTROInternational Oncology Forum
  • Place of Presentation: ロンドン(イギリス)
  • Year and Date: 2011-05-09
• [Presentation] Apolipoprotein C-IIcould be a potential biomarker as aprognostic factor of locally advancedcervical cancer after radiotherapy. (2010)
  • Author(s): Yoko Harima
  • Organizer: 96th Annual Meeting of RadiologicalSociety of North America
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2010-11-29
• [Presentation] 子宮頸部扁平上皮癌の放射線治療予後予測バイオマーカーとしてのアポリポ蛋白C-II (2010)
  • Author(s): 播磨洋子
  • Organizer: 第23回日本放射線腫瘍学会学術大会学術発表会
  • Place of Presentation: 千葉
  • Year and Date: 2010-11-19
• [Presentation] 子宮頸癌の放射線治療予後予測因子としてのアポリポ蛋白C-II (2010)
  • Author(s): 播磨洋子
  • Organizer: 第48回日本癌治療学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-30
• [Presentation] Apolipoprotein C-IIcorrelated with outcome for thepatients with advanced cervical cancerafter radiotherapy. (2010)
  • Author(s): Yoko Harima
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Prediction of prognosisof advanced cervical cancers afterradiotherapy according to real-timePCR (2010)
  • Author(s): Yoko Harima
  • Organizer: 29th ESTRO
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-09-15
• [Presentation] The combination therapy of radiotherapy, chemotherapy, andhyperthermia in Stage IIIB cervical carcinoma. Work Shop, Thermal Medicine: From Bench to Bed. (2010)
  • Author(s): Yoko harima
  • Organizer: The 5th Asian Congress of Hyperthermic Oncology (ACHO) & The 27th Japanese Congress of Thermal Medicine.
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-10
• [Presentation] 局所進行子宮頸癌の放射線治療予後予測因子のバイオマーカーとしてのアポリポ蛋白C-II (2010)
  • Author(s): 播磨洋子
  • Organizer: 第69回日本医学放射線学会学術発表会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-09
• [Book] 放射線医学 放射線 腫瘍学:女性生殖器腫瘍の放射線治療 (2012)
  • Author(s): 播磨洋子
  • Total Pages: 104-116
  • Publisher: 金芳堂
• [Book] がん放射線治療と看護の実践第1章総論2節放射線生物学の最先端トピックス (2011)
  • Author(s): 播磨洋子
  • Total Pages: 18-29
  • Publisher: 金原出版株式会社
• [Book] がん・放射線療法2010 第3章 放射線生物学:化学放射 線療法の基礎
  • Author(s): 播磨洋子
  • Total Pages: 175-181
  • Publisher: 篠原出版社