2012 Fiscal Year Final Research Report
Relationship between bioiron and neurodegenerative disease investigated through the proton relaxation rate by MRI
| Project/Area Number |
22390238
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
MITSUMORI Fumiyuki 独立行政法人国立環境研究所, 環境計測研究センター, 客員研究員 (90125229)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hidehiro 独立行政法人国立環境研究所, 環境計測研究センター, 主任研究員 (60370269)
MIYAJIMA Hiroaki 浜松医科大学, 医学部, 教授 (90221613)
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| Co-Investigator(Renkei-kenkyūsha) |
SEYAMA Haruhiko 独立行政法人国立環境研究所, 環境計測研究センター, 室長 (40142096)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 高磁場MRI / 横緩和速度 / ヒト脳 / 生体鉄 / 神経変性疾患 |
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| Research Abstract |
We developed an in vivo iron imaging method using a relationship of the observed apparent transverse relaxation rate, R2 † of human brain water, the iron concentration, [Fe], and the macromolecular mass fraction, fM (R2 † = α[Fe] + βfM + γ, α, β, γ are coefficients). Iron image obtained with a patient with aceruloplasminemia showed approximately 4 times increase in the iron concentration compared with healthy subjects in all brain regions. We also clarified that the above relationship is valid at wide range of magnetic field from 1.5 to 7T. Field dependent change in α, β, γ gave us a clue to uncover the mechanism of relaxation in human brain
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