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2013 Fiscal Year Final Research Report

Establishment of specific cancer vaccination therapy for pancreatic and biliary cancer.

Research Project

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Project/Area Number 22390253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

EGAWA Shinichi  東北大学, 災害科学国際研究所, 教授 (00270679)

Co-Investigator(Kenkyū-buntansha) HAYASHI Hiroki  東北大学, 病院, 助教 (30422124)
SAKATA Naoaki  東北大学, 病院, 助教 (50431565)
OKADA Takaho  東北大学, 病院, 助教 (10375074)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywordsペプチドワクチン / 膵癌 / 胆道癌 / 腫瘍関連抗原 / WT1 / プロテオミクス
Research Abstract

Pancreatic and biliary cancer is still poor prognostic cancer though surgical, chemotherapeutic and radiological treatment is improving. In this research, we vaccinated the highest rank tumor associated antigen WT1 peptide to patients with chemo-refractory pancreatic cancer. Median survival rate of the patients was eight month in a certain condition resulting in the prospective randomized trial. We confirmed that pancreatic adenocarcinoma, neuroendocrine tumors and acinar cell carcinoma expressed WT1 frequently. We also found new molecular targets relevant to the prognosis from the resected specimen.

  • Research Products

    (60 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (46 results) (of which Peer Reviewed: 25 results) Presentation (9 results) Book (3 results) Remarks (2 results)

  • [Journal Article] A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes2014

    • Author(s)
      Komatsu H, et al
    • Journal Title

      PLoS One

      Volume: 9(2) Pages: e87875

    • DOI

      10.1371/journal.pone.0087875.eCollection2014

    • Peer Reviewed
  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer2014

    • Author(s)
      Yamaue H, et al
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73(1) Pages: 97-102

    • DOI

      10.1007/s00280-013-2323-6

    • Peer Reviewed
  • [Journal Article] Solid pseudopapillary neoplasms of the pancreas : an 18-year experience at a single Japanese Institution2013

    • Author(s)
      Morikawa T, et al
    • Journal Title

      Surg Today

      Volume: 43(1) Pages: 26-32

    • DOI

      10.1007/s00595-012-0345-z

    • Peer Reviewed
  • [Journal Article] Randomized Phase III Study of Gemcitabine Plus S-1, S-1 Alone, or Gemcitabine Alone in Patients With Locally Advanced and Metastatic Pancreatic Cancer in Japan and Taiwan : GEST Study2013

    • Author(s)
      Ueno H, et al
    • Journal Title

      J Clin Oncol

      Volume: 31(13) Pages: 1640-8

    • DOI

      10.1200/JCO.2012.43.3680

    • Peer Reviewed
  • [Journal Article] miR-197 induces epithelialmesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol2013

    • Author(s)
      Hamada S, et al
    • Journal Title

      J Cell Physiol

      Volume: 228(6) Pages: 1255-63

    • DOI

      10.1002/jcp.24280

    • Peer Reviewed
  • [Journal Article] The expression of S100A4 in human pancreatic cancer is associated with invasion2013

    • Author(s)
      Tsukamoto N, et al
    • Journal Title

      Pancreas

      Volume: 42(6) Pages: 1027-33

    • DOI

      10.1097/MPA.0b013e31828804e7

    • Peer Reviewed
  • [Journal Article] Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer2013

    • Author(s)
      Yamamura A, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441(1) Pages: 102-7

    • DOI

      10.1016/j.bbrc.2013.10.010

    • Peer Reviewed
  • [Journal Article] Neoadjuvant chemotherapy with gemcitabine and S-1 for resectable and borderline pancreatic ductal adenocarcinoma : results from a prospective multi-institutional phase 2 trial2013

    • Author(s)
      Motoi F, et al
    • Journal Title

      Ann Surg Oncol

      Volume: 20(12) Pages: 3794-801

    • DOI

      10.1245/s10434-013-3129-9

    • Peer Reviewed
  • [Journal Article] Parametric estimation of cure rate in gastric, colonic and pancreatic cancers2013

    • Author(s)
      Maetani S, et al
    • Journal Title

      Tenri Med Bullet

      Volume: 16(2) Pages: 70-78

    • DOI

      10.12936/tenrikiyo.16-017

    • Peer Reviewed
  • [Journal Article] Infiltration of CD40-Positive tumor-associated macrophages indicates a favorable prognosis in colorectal cancer patients2013

    • Author(s)
      Kinouchi M, et al
    • Journal Title

      Hepatogastroenterology

      Volume: 60(121) Pages: 83-8

    • DOI

      10.5754/hge12372

    • Peer Reviewed
  • [Journal Article] ヒト各種膵腫瘍における腫瘍関連抗原WT1 の免疫組織学的検討2013

    • Author(s)
      申榮柱 (指導:江川新一)
    • Journal Title

      修士論文

  • [Journal Article] 疫学からみた膵癌の高危険群と早期診断2013

    • Author(s)
      江川新一, 他
    • Journal Title

      肝胆膵

      Volume: 66(2) Pages: 251-259

  • [Journal Article] 膵癌に対する樹状細胞療法2013

    • Author(s)
      砂村眞琴, 他
    • Journal Title

      臨床外科

      Volume: 68(8) Pages: 926-933

  • [Journal Article] Nm23/Nucleoside Diphosphate Kinase-A as a Potent Prognostic marker in Invasive Pancreatic Ductal Carcinoma Identified by Proteomic Analysis of Laser Micro-dissected Formalin-Fixed Paraffin-Embedded Tissue2012

    • Author(s)
      Takadate T, et al
    • Journal Title

      Clin Proteomics

      Volume: 9(1) Pages: 8-18

    • DOI

      10.1186/1559-0275-9-8

    • Peer Reviewed
  • [Journal Article] Distal pancreatectomy (with video)2012

    • Author(s)
      Egawa S, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 19 Pages: 135-140

    • DOI

      10.1007/s00534-011-0471-9

    • Peer Reviewed
  • [Journal Article] Middle pancreatectomy2012

    • Author(s)
      Motoi F, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 19 Pages: 148-151

    • DOI

      10.1007/s00534-011-0477-3

    • Peer Reviewed
  • [Journal Article] Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line : Targeted proteomic and metabolomics analyses in PK9 cells2012

    • Author(s)
      Ohmine K, et al
    • Journal Title

      Pharm Res

      Volume: 29(7) Pages: 2006-16

    • DOI

      10.1007/s11095-012-0728-2

    • Peer Reviewed
  • [Journal Article] Lymph node metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma2012

    • Author(s)
      Katayose Y, et al
    • Journal Title

      Hepato-Gastroenterol

      Volume: 59 Pages: 1758-1760

    • DOI

      10.5754/hge11806

    • Peer Reviewed
  • [Journal Article] An analysis of a second-line S-1 monotherapy for gemcitabinerefractory biliary tract cancer2012

    • Author(s)
      Katayose Y, et al
    • Journal Title

      Hepatogastroenterology

      Volume: 59(115) Pages: 691-5

    • DOI

      10.5754/hge11530

    • Peer Reviewed
  • [Journal Article] DCK is frequently inactivated in acquired gemcitabine- resistant human cancer cells2012

    • Author(s)
      Saiki Y, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 421(1) Pages: 98-104

    • DOI

      10.1016/j.bbrc.2012.03.122

    • Peer Reviewed
  • [Journal Article] Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy2012

    • Author(s)
      Motoi F, et al
    • Journal Title

      Br J Surg

      Volume: 99 Pages: 524-531

    • Peer Reviewed
  • [Journal Article] Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system2012

    • Author(s)
      Shima K, et al
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 31 Pages: 55-61

    • DOI

      10.1186/1756-9966-31-55

    • Peer Reviewed
  • [Journal Article] 膵癌切除例における術前補助化学療法2012

    • Author(s)
      江川新一, 他
    • Journal Title

      癌の臨床

      Volume: 58(5) Pages: 247-254

  • [Journal Article] 膵癌 5)術前術後補助療法の現状と課題2012

    • Author(s)
      江川新一, 他
    • Journal Title

      腫瘍内科

      Volume: 9(6) Pages: 718-726

  • [Journal Article] 膵神経内分泌腫瘍の外科2012

    • Author(s)
      江川新一, 他
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 29(1) Pages: 39-42

  • [Journal Article] 胆道癌①術前療法2012

    • Author(s)
      片寄友, 他
    • Journal Title

      臨床外科

      Volume: 66 Pages: 190-195

  • [Journal Article] Severe cholestatic liver failure associated with gemcitabine adjuvant monotherapy for pancreatic cancer2011

    • Author(s)
      Okada T, et al
    • Journal Title

      Clin J Gastroenterol

      Volume: 4 Pages: 391-395

    • Peer Reviewed
  • [Journal Article] Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer : a retrospective study2011

    • Author(s)
      Maeda S, et al
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Pages: 539-545

    • DOI

      10.1007/s10147-011-0220-8

    • Peer Reviewed
  • [Journal Article] Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas2011

    • Author(s)
      Furukawa T, et al
    • Journal Title

      Gut

      Volume: 60 Pages: 509-516

    • DOI

      10.1136/gut.2010.210567

    • Peer Reviewed
  • [Journal Article] 小膵癌2011

    • Author(s)
      江川新一, 他
    • Journal Title

      別冊日本臨牀

      Volume: 16 Pages: 2た81-284

  • [Journal Article] 胆管癌に対する術前化学療法による集学的治療2011

    • Author(s)
      片寄友, 他
    • Journal Title

      消化器内科

      Volume: 52 Pages: 420-424

  • [Journal Article] 膵癌登録からみた膵癌取扱い規約とWHO 分類の異同と課題2011

    • Author(s)
      江川新一
    • Journal Title

      胆と膵

      Volume: 32 Pages: 1279-1288

  • [Journal Article] 膵癌5. 外科治療の進歩2011

    • Author(s)
      江川新一, 他
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 37-42

  • [Journal Article] 浸潤性膵管癌切除後6 年間無再発であった異時性浸潤性膵管癌の1 例2011

    • Author(s)
      三浦孝之, 他
    • Journal Title

      日本消化器外科学会雑誌

      Volume: 45 Pages: 304-311

  • [Journal Article] Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer2010

    • Author(s)
      Oishi H, et al
    • Journal Title

      Pancreas

      Volume: 39 Pages: 897-903

    • DOI

      10.1097/MPA.0b013e3181ce7185

    • Peer Reviewed
  • [Journal Article] Major hepatectomy for perihilar cholangio-carcinoma2010

    • Author(s)
      Unno M, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17 Pages: 463-469

    • DOI

      10.1007/s00534-009-0206-3

    • Peer Reviewed
  • [Journal Article] 膵癌に対するWT1 ペプチドワクチン治療の背2010

    • Author(s)
      江川新一, 他
    • Journal Title

      胆と膵

      Volume: 32 Pages: 141-144

  • [Journal Article] 膵癌登録-臓器がん登録の現状と将来展望-臨床へのフィードバックを目指して-2010

    • Author(s)
      江川新一, 他
    • Journal Title

      外科治療

      Volume: 104 Pages: 378-386

  • [Journal Article] Stage IV 局所進行膵癌の治療戦略 : 術前治療(NAC)とR0 切除を目的とした後腹膜一括切除(en-bloc dissection: EBD2010

    • Author(s)
      元井冬彦, 他
    • Journal Title

      消化器内科

      Volume: 50 Pages: 288-296

  • [Journal Article] 膵癌における進行度診断2010

    • Author(s)
      乙供茂, 他
    • Journal Title

      消化器外科

      Volume: 33 Pages: 1049-1056

  • [Journal Article] 無治療にて2 年9 カ月経過後に治癒切除施行し得た胆管内発育型肝内胆管癌の1 例2010

    • Author(s)
      森川孝則, 他
    • Journal Title

      胆道

      Volume: 24 Pages: 105-111

  • [Journal Article] 食道癌術後胃管浸潤を来した広義の肝門部胆管癌および下咽頭癌の同時性重複癌の1 例2010

    • Author(s)
      高舘達之, 他
    • Journal Title

      日本胆道学会雑誌

      Volume: 24 Pages: 204-208

  • [Journal Article] 術前治療とR0をめざした後腹膜一括郭清2010

    • Author(s)
      元井冬彦, 他
    • Journal Title

      外科

      Volume: 72 Pages: 734-742

  • [Journal Article] 病期群別解析による膵癌切除例の長期生存の条件2010

    • Author(s)
      元井冬彦, 他
    • Journal Title

      消化器内科

      Volume: 51 Pages: 173-179

  • [Journal Article] 全国登録による膵癌切除術後長期生存者の解析2010

    • Author(s)
      江川新一
    • Journal Title

      消化器内科

      Volume: 51 Pages: 154-161

  • [Journal Article] Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues

    • Author(s)
      Takadate T, et al
    • Journal Title

      Int J Cancer

      Volume: 132(6) Pages: 1368-82

    • DOI

      10.1002/ijc.27797

    • Peer Reviewed
  • [Presentation] Long-term follow up of Wilms Tumor 1 (WT1) peptide vaccinated patients with chemorefractory advanced pancreatic cancer2012

    • Author(s)
      Egawa S, et al
    • Organizer
      6th International Symposium on WT1 in Human Neoplasia
    • Place of Presentation
      京都
    • Year and Date
      2012-11-22
  • [Presentation] 切除可能膵癌に対する化学療法の新しい展開2012

    • Author(s)
      江川新一, 他
    • Organizer
      第50回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-26
  • [Presentation] 膵神経内分泌腫瘍(pNET)の外科治療2012

    • Author(s)
      江川新一, 他
    • Organizer
      第67回日本消化器外科学会(
    • Place of Presentation
      富山
    • Year and Date
      2012-07-19
  • [Presentation] 膵体尾部切除2012

    • Author(s)
      江川新一, 他
    • Organizer
      第24回日本肝胆膵外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-30
  • [Presentation] 膵癌切除例における術前補助化学療法2012

    • Author(s)
      江川新一, 他
    • Organizer
      第98回日本消化器病学会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
  • [Presentation] 膵癌切除例における術前補助化学療法2012

    • Author(s)
      江川新一, 他
    • Organizer
      第112回日本外科学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2012-04-12
  • [Presentation] Pilot trial of Wilms Tumor 1 (WT1) peptide vaccine therapy for chemorefractory advanced pancreatic cancer2011

    • Author(s)
      Egawa S, et al
    • Organizer
      5th Intenational Conference of WT1 in Human Neoplasia
    • Place of Presentation
      トリノ, イタリア
    • Year and Date
      2011-04-15
  • [Presentation] Pilot trial of Wilms tumor 1 (WT1) peptide vaccine therapy for chemorefractory advanced pancreatic cancer2011

    • Author(s)
      Egawa S, et al
    • Organizer
      Joint meeting of International Association for Pancreatology and Indian Pancreas Club
    • Place of Presentation
      コーチン, インド
    • Year and Date
      2011-02-12
  • [Presentation] 薬剤耐性の進行・再発膵癌に対する抗癌剤を併用したWT1 ペプチドワクチン療法2010

    • Author(s)
      江川新一, 他
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      山口
    • Year and Date
      2010-07-15
  • [Book] わが国における膵がんの現状. 舩越顕博 編, インフォームドコンセントのための図説シリーズ膵がん 改訂3版2013

    • Author(s)
      江川新一
    • Total Pages
      36-45
    • Publisher
      医薬ジャーナル社
  • [Book] CQ2-1 Stage Iva 膵癌に対する手術的切除療法の意義はあるか? 日本膵臓学会. 科学的根拠に基づく膵癌診療ガイドライン2013年版2013

    • Author(s)
      江川新一
    • Total Pages
      55-57
    • Publisher
      金原出版
  • [Book] CQ2-8 膵癌では手術例数の多い施設で治療を受けるのがよいか? 日本膵臓学会. 科学的根拠に基づく膵癌診療ガイドライン2013年版2013

    • Author(s)
      江川新一
    • Total Pages
      76-79
    • Publisher
      金原出版
  • [Remarks]

    • URL

      http://www.surg1.med.tohoku.ac.jp/

  • [Remarks]

    • URL

      http://www.irides-icdm.med.tohoku.ac.jp/index.html

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Published: 2015-06-25  

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