2012 Fiscal Year Final Research Report
The development of novel therapy combined LVAD and regenerative medicine for severe heart failure patients
| Project/Area Number |
22390266
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURATANI Toru 大阪大学, 大学院・医学系研究科, 寄附講座教授 (90448035)
UENO Takayoshi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (60437316)
SAKAGUCHI Taichi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (10467574)
YOSHIKAWA Yasushi 大阪大学, 大学院・医学系研究科, 助教 (40570594)
YAMAUCHI Takashi 大阪大学, 大学院・医学系研究科, 助教 (20527999)
SHIRAKAWA Yukitoshi 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (20457013)
SAWA Yoshiki 大阪大学, 大学院・医学系研究科, 教授 (00243220)
SHIMAMURA Kazuo 大阪大学, 医学部附属病院, 医員 (10507205)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 人工心臓 / 再生医療 / 心不全 / 幹細胞 / 左室形成デバイス / 心不全薬 |
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| Research Abstract |
In this project we evaluated histologies of heart tissue at LVAD implantation and heart transplantation. We performed myoblast sheet implantation to cardiomyopathy patients as clinical trial. We implanted myoblast sheet to 4 dilated cardiomyopathy (DCM) patients who received LVAD, 7 DCM patients without LVAD, and 8 ICM patients without LVAD. 2 of 4 DCM patients who received LVAD showed bridge to recovery from LVAD. In one DCM patient who could not show functional recovery after myoblast sheet implantation, we could not detect implanted myoblasts in heart sample obtained at heart transplantation in spite of histological angiogenesis and enhanced expression of cytoskeletal protains in myocytes. We could detect hypertrophy in smooth muscle layer in microvasculature in continuous flow LVAD compared with pulsatile flow LVAD, suggesting that poor functional recovery after LVAD implantation because of decrease of blood perfusion in continuous flow LVAD.
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[Journal Article] Improvement of Cardiac Stem Cell-Sheet Therapy for Chronic Ischemic Injury by Adding Endothelial Progenitor Cell Transplantation: Analysis of Layer-Specific Regional Cardiac Function2013
Author(s)
Kamata S, Miyagawa S, Fukushima S, Nakatani S, Kawamoto A, Saito A, Harada A, Shimizu T, Daimon T, Okano T, Asahara T, Sawa Y
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Journal Title
URL
Peer Reviewed
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[Journal Article] Initial report of bridge to recovery in a patient with DuraHeart LVAD2013
Author(s)
Yoshioka D, Toda K, Sakaguchi T, Miyagawa S, Nishi H, Yoshikawa Y, Fukushima S, Saito S, Saito T, Shibasaki I, Sakata Y, Ohtani T, Sawa Y
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Journal Title
J Artif Organs
Pages: 1-3
DOI
Peer Reviewed
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[Journal Article] Myocardial layer-specific effect of myoblast cell-sheet implantation evaluated by tissue strain imaging2012
Author(s)
Shudo Y, Miyagawa S, Nakatani S, Fukushima S, Sakaguchi T, Saito A, Asanuma T, Kawaguchi N, Matsuura N, Shimizu T, Okano T, Sawa Y
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Journal Title
Circ J
Volume: 77(4)
Pages: 1063-72
URL
Peer Reviewed
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[Journal Article] Myoblast sheet can prevent the impairment of cardiac diastolic function and late remodeling after left ventricular restoration in ischemic cardiomyopathy2012
Author(s)
Saito S, Miyagawa S, Sakaguchi T, Imanishi Y, Iseoka H, Nishi H, Yoshikawa Y, Fukushima S, Saito A, Shimizu T, Okano T, Sawa Y
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Journal Title
Transplantation
Volume: 93(11)
Pages: 1108-15
DOI
Peer Reviewed
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[Journal Article] Impaired myocardium regeneration with skeletal cell sheets--a preclinical trial for tissue-engineered regeneration therapy2010
Author(s)
Miyagawa S, Saito A, Sakaguchi T, Yoshikawa Y, Yamauchi T, Imanishi Y, Kawaguchi N, Teramoto N, Matsuura N, Iida H, Shimizu T, Okano T, Sawa Y
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Journal Title
Transplantation
Volume: 90(4)
Pages: 364-72
DOI
Peer Reviewed
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