2012 Fiscal Year Final Research Report
The significance of COX-2 expression and therapeutic application in malignant gliomas
| Project/Area Number |
22390279
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Masahiro 九州大学, 大学病院, 講師 (50380621)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 悪性神経膠腫 / COX-2 / mesenchymal |
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| Research Abstract |
The expression level of COX-2 in glioma tissues positively correlated with tumor malignancy and mesenchymal marker expression. These results suggest that COX-2 induction is associated with the tumor characteristics such as invasion and angiogenesis. By contrast, COX-2 expression in glioma stem cells which grow in neurosheres is decreased or almost absent. Therefore, it can be concluded that COX-2 expression is not implicated in the proliferation and selfrenewal of glioma stem cells.
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[Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma2012
Author(s)
Ma X, Yoshimoto K, Guan Y, Hata N, Mizoguchi M, Sagata N, Murata H, Kuga D, Amano T, Nakamizo A, Sasaki T
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Journal Title
Neuro-Oncology
Volume: 14(9)
Pages: 1153-1162
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