2012 Fiscal Year Final Research Report
Identification of transcription factors that regulate tendon/ligament formation
| Project/Area Number |
22390289
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SHUKUNAMI Chisa 京都大学, 再生医科学研究所, 准教授 (60303905)
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| Research Collaborator |
SUGIMOTO Yuki 京都大学, 再生医科学研究所, 研究生
SHIMAMURA Satoko 京都大学, 再生医科学研究所, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Keywords | 転写因子 / Tenomodulin / 腱 / 靱帯 / 運動器 |
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| Research Abstract |
Mouse Tenomodulin (Tnmd)is predominantly expressed in dense connective tissues such as tendons and ligaments. We identified the enhancer regions near the promoter and within the intron 2 of the mouseTnmdgene. We found that these enhancer regionsare transactivated by the transcription factors of basic helix-loop-helix, Ets, or Sox family.
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[Journal Article] Tenomodulin expression in the periodontal ligament enhances cellular adhesion2013
Author(s)
Y. Komiyama, S. Ohba, N. Shimohata, K. Nakajima, H. Hojo, F. Yano, T. Takato, D. Docheva, C. Shukunami, Y. Hiraki, and UI. Chung.
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Journal Title
PLoS One
Volume: 8
Pages: e60203
DOI
Peer Reviewed
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