2012 Fiscal Year Final Research Report
Investigation of molecular machamism of periopearetive oxygen metabolism regulation by hypoxia-inducible factors
| Project/Area Number |
22390298
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto University |
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Principal Investigator |
HIROTA Kiichi 京都大学, 医学研究科, 准教授 (00283606)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHINO Yuma 京都大学, 医学研究科, 特任講師 (00378746)
KONDOH Shinae 東京工業大学, 生命理工学研究科, 教授 (40314182)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬理学 / 麻酔薬 / 低酸素応答 / 細胞生物学 / 分子生物学 |
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| Research Abstract |
Oxygen is one of the most important vital molecules for almost all higher organism including human beings. In contrast, excessive oxygen is cytotoxic. A bottom line of the perioperative patient care is to maintain oxygen supply/demand within a narrow optimized range. Hypoxia-inducible factors (HIFs) play a central role in regulation of oxygen homeostasis. To investigate the dynamism of perioperative oxygen metabolism from the point of view of HIFs, we have established the experimental systems adopting cultured cells and experimental animals and obtained several experimental results.
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Research Products
(28 results)
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[Journal Article] Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells2013
Author(s)
Y. Zhu, T. Zhao, S. Itasaka, L. Zeng, C.J. Yeom, K. Hirota, K. Suzuki, A. Morinibu, K. Shinomiya, G. Ou, M. Yoshimura, M. Hiraoka, H. Harada
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Journal Title
Oncogene
Volume: 32
Pages: 2058 - 2068
DOI
Peer Reviewed
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[Journal Article] Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels2012
Author(s)
H. Harada, M. Inoue, S. Itasaka, K. Hirota,A. Morinibu, K. Shinomiya, L. Zeng, G. Ou, Y. Zhu, M. Yoshimura, W.G. McKenna, R.J. Muschel, M. Hiraoka
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Journal Title
Nature communications
Volume: 3
Pages: 783
DOI
Peer Reviewed
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[Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging2011
Author(s)
T. Kadonosono, T. Kuchimaru, S. Yamada, Y. Takahashi, A. Murakami, T. Tani, H. Watanabe, T. Tanaka, K. Hirota, M. Inoue, T. Tsukamoto, T. Toyoda, K. Urano, K. Machida, T. Eto, T. Ogura, H. Tsutsumi, M. Ito, M. Hiraoka, G. Kondoh, S. Kizaka-Kondoh
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Journal Title
PLoS ONE
Volume: 6
Pages: e26640
DOI
Peer Reviewed
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[Journal Article] Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent manner2011
Author(s)
H. Daijo, S. Kai, T. Tanaka, T. Wakamatsu, S. Kishimoto, K. Suzuki, H. Harada, S. Takabuchi, T. Adachi, K. Fukuda, K. Hirota
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Journal Title
Eur J Pharmacol
Volume: 667
Pages: 144-152
DOI
Peer Reviewed
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