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2012 Fiscal Year Final Research Report

Delineation of Molecular Mechanisms and Identification of Molecular Therapeutic Targets underlying Progression of Urologic Cancers Associated with High Fat or High Calorie Diet

Research Project

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Project/Area Number 22390302
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionAkita University

Principal Investigator

HABUCHI Tomonori  秋田大学, 大学院・医学系研究科, 教授 (00293861)

Co-Investigator(Kenkyū-buntansha) OHYAMA Chikara  弘前大学, 大学院・医学系研究科, 教授 (80282135)
TSUCHIYA Norihiko  秋田大学, 大学院・医学系研究科, 准教授 (70282176)
YUASA Takeshi  財団法人癌研究会, 附属病院・化学療法科 (00314162)
NANJO Hiroshi  秋田大学, 医学部, 教授 (70250892)
HORIKAWA Yohei  秋田大学, 医学部, 講師 (40361232)
Project Period (FY) 2010 – 2012
Keywords肥満 / 高脂肪食 / 前立腺癌 / 腎細胞癌 / IGF-1
Research Abstract

Accumulating evidence suggests that dietary patterns including high-fat diet (HFD) and high-calorie diet (HCD) play an important role in progression of urologic malignancies such as prostate cancer and renal cell cancer. However, which of these diets have the greatest effect on tumor progression and its underlying mechanisms remains unclear. The purpose of this research project was to delineate molecular mechanisms and identify molecular therapeutic targets underlying progression of urologic cancers associated with high fat or high calorie diet.

  • Research Products

    (33 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (20 results) Presentation (8 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis2013

    • Author(s)
      Tsuchiya N, Narita S, Inoue T, Saito M, Numakura K, Huang M, Hatakeyama S, Satoh S, Saito S, Ohyama C, Arai Y, Ogawa O, Habuchi T.
    • Journal Title

      BMC Cancer

      Volume: 13(1) Pages: 150

  • [Journal Article] The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators; The Australian Prostate Cancer Bioresource; The PRACTICAL Consortium, Chanock S, Gronberg H, Haiman CA, Kraft P, Easton DF, Eeles RA. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease2013

    • Author(s)
      Amin Al Olama A, Kote-Jarai Z, Schumacher FR, Wiklund F, Berndt SI, Benlloch S, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Hunter DJ, Henderson BE, Thun MJ, Gaziano M, Giovannucci EL, Siddiq A, Travis RC, Cox DG, Canzian F, Riboli E, Key TJ, Andriole G, Albanes D, Hayes RB, Schleutker J, Auvinen A, Tammela TL, Weischer M, Stanford JL, Ostrander EA, Cybulski C, Lubinski J, Thibodeau SN, Schaid DJ, Sorensen KD, Batra J, Clements JA, Chambers S, Aitken J, Gardiner RA, Maier C, Vogel W, Dork T, Brenner H, Habuchi T, Ingles S, John EM, Dickinson JL, Cannon-Albright L, Teixeira MR, Kaneva R, Zhang HW, Lu YJ, Park JY, Cooney KA, Muir KR, Leongamornlert DA, Saunders E, Tymrakiewicz M, Mahmud N, Guy M, Govindasami K, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English D, Virtamo J, Le Marchand L, Campa D, Kaaks R, Lindstrom S, Diver WR, Gapstur S, Yeager M, Cox A, Stern MC, Corral R, Aly M, Isaacs W, Adolfsson J, Xu J, Zheng SL, Wahlfors T, Taari K, Kujala P, Klarskov P, Nordestgaard BG, Roder MA, Frikke-Schmidt R, Bojesen SE, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Rinckleb A, Luedeke M, Herkommer K, Meyer A, Serth J, Marthick JR, Patterson B, Wokolorczyk D, Spurdle A, Lose F, McDonnell SK, Joshi AD, Shahabi A, Pinto P, Santos J, Ray A, Sellers TA, Lin HY, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V
    • Journal Title

      Hum Mol Genet

      Volume: 22(2) Pages: 408-415

  • [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese2012

    • Author(s)
      Akamatsu S, Takahashi A, Takata R, Kubo M, Inoue T, Morizono T, Tsunoda T, Kamatani N, Haiman CA, Wan P, Chen GK, Le Marchand L, Kolonel LN, Henderson BE, Fujioka T, Habuchi T, Nakamura Y, Ogawa O, Nakagawa H.
    • Journal Title

      PLoS One

      Volume: 7(10) Pages: e46454

  • [Journal Article] A high-fat diet enhances proliferation of prostate cancer cells and activates MCP-1/CCR2 signaling2012

    • Author(s)
      Huang M, Narita S, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Tsuchiya N, Habuchi T.
    • Journal Title

      Prostate

      Volume: 72(16) Pages: 1779-88

  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • Author(s)
      Akamatsu S , Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, and Nakagawa H.
    • Journal Title

      Nat Genet

      Volume: 44(4) Pages: 426-9

  • [Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease2012

    • Author(s)
      Inoue T, Matsuura K, Yoshimoto T, Nguyen LT, Tsukamoto Y, Nakada C, Hijiya N, Narimatsu T, Nomura T, Sato F, Nagashima Y, Kashima K, Hatakeyama S, Ohyama C, Numakura K, Habuchi T, Nakagawa M, Seto M, Mimata H, Moriyama M.
    • Journal Title

      Cancer Sci

      Volume: 103(3) Pages: 569-76

  • [Journal Article] Outcome, clinical prognostic factors and genetic predictors of adverse reactions of intermittent combination chemotherapy with docetaxel estramustine phosphate and carboplatin for castration-resistant prostate cancer2012

    • Author(s)
      Narita S, Tsuchiya N, Yuasa T, Maita S, Obara T, Numakura K, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
    • Journal Title

      Int J Clin Oncol

      Volume: 17(3) Pages: 204-11

  • [Journal Article] Antitumor effect of sunitinib against skeletal metastatic renal cell carcinoma through inhibition of osteoclast function2012

    • Author(s)
      Maita S, Yuasa T, Tsuchiya N, Mitobe Y, Narita S, Horikawa Y, Hatake K, Fukui I, Kimura S, Maekawa T, Habuchi T.
    • Journal Title

      Int J Cancer

      Volume: 130(3) Pages: 677-84

  • [Journal Article] Overexpression of Fn14 promotes androgen-independent prostate cancer progression through MMP-9 and correlates with poor treatment outcome2011

    • Author(s)
      Huang M, Narita S, Tsuchiya N, Ma Z, Numakura K, Obara T, Tsuruta H, Saito M, Inoue T, Horikawa Y, Satoh S, Habuchi T.
    • Journal Title

      Carcinogenesis

      Volume: 32(11) Pages: 1589-96

  • [Journal Article] Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study2011

    • Author(s)
      Kote-Jarai Z, Olama AA, Giles GG, Severi G, Schleutker J, Weischer M, Campa D, Riboli E, Key T, Gronberg H, Hunter DJ, Kraft P, Thun MJ, Ingles S, Chanock S, Albanes D, Hayes RB, Neal DE, Hamdy FC, Donovan JL, Pharoah P, Schumacher F, Henderson BE, Stanford JL, Ostrander EA, Sorensen KD, Dork T, Andriole G, Dickinson JL, Cybulski C, Lubinski J, Spurdle A, Clements JA, Chambers S, Aitken J, Gardiner RA, Thibodeau SN, Schaid D, John EM, Maier C, Vogel W, Cooney KA, Park JY, Cannon-Albright L, Brenner H, Habuchi T, Zhang HW, Lu YJ, Kaneva R, Muir K, Benlloch S, Leongamornlert DA, Saunders EJ, Tymrakiewicz M, Mahmud N, Guy M, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English DR, Wahlfors T, Tammela TL, Klarskov P, Nordestgaard BG, Roder MA, Tybjarg-Hansen A, Bojesen SE, Travis R, Canzian F, Kaaks R, Wiklund F, Aly M, Lindstrom S, Diver WR, Gapstur S, Stern MC, Corral R, Virtamo J, Cox A, Haiman CA, Le Marchand L, Fitzgerald L, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Meyer A, Serth J, Yeager M, Berndt SI, Marthick JR, Patterson B, Wokolorczyk D, Batra J, Lose F, McDonnell SK, Joshi AD, Shahabi A, Rinckleb AE, Ray A, Sellers TA, Lin HY, Stephenson RA, Farnham J, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V; The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; The UK ProtecT Study Collaborators, The Australian Prostate Cancer BioResource; The PRACTICAL Consortium, Easton DF, Eeles RA.
    • Journal Title

      Nat Genet

      Volume: 43(8) Pages: 785-91

  • [Journal Article] A Novel Strategy for Evasion of NK Cell Immunity by Tumours Expressing Core2 O-glycans2011

    • Author(s)
      Tsuboi S, Sutoh M, Hatakeyama S, Hiraoka N, Habuchi T, Horikawa Y, Hashimoto Y, Yoneyama T, Mori K, Koie T, Nakamura T, Saitoh H, Yamaya K, Funyu T, Fukuda M, Ohyama C.
    • Journal Title

      EMBO J.

      Volume: 30(15) Pages: 3173-85

  • [Journal Article] Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility2011

    • Author(s)
      Kawata N, Tsuchiya N, Horikawa Y, Inoue T, Tsuruta H, Maita S, Sato S, Mitobe Y, Narita S, Habuchi T.
    • Journal Title

      Int J Cancer

      Volume: 129(8) Pages: 1872-80

  • [Journal Article] Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer2010

    • Author(s)
      Ma Z, Tsuchiya N, Yuasa T, Huang M, Obara T, Narita S, Horikawa Y, Tsuruta H, Saito M, Satoh S, Ogawa O, Habuchi T.
    • Journal Title

      J Urol

      Volume: 184(3) Pages: 1182-8

  • [Journal Article] Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer2009

    • Author(s)
      Tsuchiya N, Narita S, Kumazawa T, Inoue T, Ma Z, Tsuruta H, Saito M, Horikawa Y, Yuasa T, Satoh S, Ogawa O, Habuchi T.
    • Journal Title

      Oncol Rep

      Volume: 22(3) Pages: 493-9

  • [Journal Article] The novel tumor-suppressor Mel-18 in prostate cancer: Its functional polymorphism, expression, and clinical significance2009

    • Author(s)
      Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, Saito M, Hu W, Ogawa O, Habuchi T
    • Journal Title

      Int J Cancer

      Volume: 125(12) Pages: 2836-43

  • [Journal Article] Intravesical administration of gammadelta T cells successfully prevents the growth of bladder cancer in the murine model2009

    • Author(s)
      Yuasa T, Sato K, Ashihara E, Takeuchi M, Maita S, Tsuchiya N, Habuchi T, Maekawa T, Kimura S
    • Journal Title

      Cancer Immunol Immunother

      Volume: 58(4) Pages: 493-502

  • [Journal Article] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population2008

    • Author(s)
      Ma Z, Tsuchiya N, Yuasa T, Inoue T, Kumazawa T, Narita S, Horikawa Y, Tsuruta H, Obara T, Saito M, Satoh S, Ogawa O, Habuchi T.
    • Journal Title

      Int J Cancer

      Volume: 123(11) Pages: 2574-2579

  • [Journal Article] Bone mineral density in Japanese prostate cancer patients under androgen-deprivation therapy2008

    • Author(s)
      Wang W, Yuasa T, Tsuchiya N, Maita S, Kumazawa T, Inoue T, Saito M, Ma Z, Obara T, Tsuruta H, Satoh S, Habuchi T.
    • Journal Title

      Endocr Relat Cancer

      Volume: 15(4) Pages: 943-52

  • [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population2008

    • Author(s)
      Terada N, Tsuchiya N, Ma Z, Shimizu Y, Kobayashi T, Nakamura E, Kamoto T, Habuchi T, Ogawa O.
    • Journal Title

      Prostate

      Volume: 68(15) Pages: 1689-95

  • [Journal Article] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer2008

    • Author(s)
      Narita N, Yuasa T, Tsuchiya N, Kumazawa T, Narita S, Inoue T, Ma Z, Saito M, Horikawa Y, Satoh S, Ogawa O, Habuchi T
    • Journal Title

      BMC Cancer

      Volume: 8 Pages: 224

  • [Presentation] Functional mononucleotide repeats in the HGF promoter are associated with bladder cancer progression2012

    • Author(s)
      Chiba, S., Horaikawa, Y., Maita, S., Numakura, K., Obara, T., Inoue, T., Narita, S., Tsuchiya, N., Satoh, S.and Habuchi, T.
    • Organizer
      The 107th annual meeting of the American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20120500
  • [Presentation] Functional genetic polymorphisms in the CYP19 gene decrease the risk of prostate cancer and alter the response to androgen deprovation therapy2012

    • Author(s)
      Kanda, S., Tsuchiya, N., Kou, M., Chiba, S., Satoyoshi, K., Maita, S., Numakura, K., Obara, T., Inoue, T., Narita, S., Horikawa, Y., Satoh, S.and Habuchi, N.
    • Organizer
      The 107th annual meeting of the American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20120500
  • [Presentation] Stimulation of macrophage inhibitory cytokine-1 by palmitic acid activates prostate cancer cell invasiveness2012

    • Author(s)
      Huang, M., Narita, S., Maita, S., Numakura, K., Obara, T., Inoue, T., Horikawa, Y., Satoh, S.and Habuchi, T.
    • Organizer
      The 107th annual meeting of the American Urological Association
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20120500
  • [Presentation] Prediction of Survival in Metastatic Prostate Cancer Patients by SNP Array Analysis of Cancer-Associated Genes2011

    • Author(s)
      Tsuchiya, N., Matsui, S., Narita, S., Inoue, T., Numakura, K., Horikawa, Y., Hatakeyama, S., Ogawa, O., Arai, Y., Saito, S., Ohyama, C., Habuchi, T.
    • Organizer
      The 106th Annunal Meeting of the American Urological Association
    • Place of Presentation
      Washisnton DC, USA
    • Year and Date
      20110500
  • [Presentation] Prostate cancer progression under high fat diet is enhanced by the MCP-1/CCR2 signaling2011

    • Author(s)
      Huang, M., Narita, S., Numakura, K., Tsuruta, H., Saito, M., Inoue, T., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • Organizer
      The 106th Annunal Meeting of the American Urological Association
    • Place of Presentation
      Washisnton DC, USA
    • Year and Date
      20110500
  • [Presentation] GENETIC POLYMORPHISM INFLUENCES INDIVIDUAL VARIATIONS IN SERUM TESTOSTERONE LEVELS IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY2010

    • Author(s)
      Narita, S., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • Organizer
      The 105th Annual Meeting of the American Urological Association, May
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20100500
  • [Presentation] INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION2010

    • Author(s)
      Tsuchiya, N., Narita, S., Ma, Z., Horikawa, Y., Tsuruta, H., Numakura, K., Saito, M., Satoh, S., Inoue, T., Ogawa, O., Habuchi. T.
    • Organizer
      The 105th Annual Meeting of the American Urological Association
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20100500
  • [Presentation] TWEAK-FN14 SIGNALING REGULATES ANDROGEN-INDEPENDENT PROSTATE CANCER CELL INVASIVENESS AND CORRELATES WITH POOR PATIENT OUTCOME2010

    • Author(s)
      Mingguo, H., Narita, S., Ma, Z., Numakura, K., Obara, T., Tsuruta, H., Saito, M., Horikawa, Y., Tsuchiya, N., Habuchi, T.
    • Organizer
      The 105th Annual Meeting of the American Urological Association
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20100500
  • [Book] Humana Press, Springer US, New York2011

    • Author(s)
      Habuchi, T.
    • Total Pages
      139-163
    • Publisher
      Prognostic Markers for Bladder Cancer. In: "Bladder Tumors: Molecular Aspects and Clinical Management
  • [Book] Inc. New York2011

    • Author(s)
      Habuchi, T. and Kakizoe, T
    • Total Pages
      295-315 (Chapter 16)
    • Publisher
      Clonality of Multifocal Urothelial Cancer and Field Cancerization. In: Field Cancerization- Basic science and clinical applications- , Nova Science Publishers
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/

  • [Patent(Industrial Property Rights)] 前立腺癌の予後の予測方法2013

    • Inventor(s)
      羽渕友則、 土谷順彦
    • Industrial Property Rights Holder
      国立大学法人秋田大学
    • Industrial Property Number
      特許2011-186698
    • Filing Date
      2013-03-14
  • [Patent(Industrial Property Rights)] 前立腺癌の予後の予測方法2012

    • Inventor(s)
      羽渕友則、 土谷順彦
    • Industrial Property Rights Holder
      国立大学法人秋田大学
    • Industrial Property Number
      特許PF000464-PCT
    • Filing Date
      20120000
    • Overseas

URL: 

Published: 2014-08-29  

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