2012 Fiscal Year Final Research Report
Molecular mechanism of dry eye disease
| Project/Area Number |
22390326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ドライアイ / 涙腺 / 酸化ストレス / 老化 |
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| Research Abstract |
The purpose of this study was to elucidate molecular mechanisms of pathogenesis in dry eye associated with lacrimal secretory hypofunction caused by increased oxidative stressand aging. We demonstrated that the increased oxidative stress with aging induce
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Research Products
(14 results)
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[Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu,Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice.2012
Author(s)
Kojima T, Wakamatsu T, Dogru M, Ogawa Y, Igarashi A, Ibrahim O, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
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Journal Title
Am J Pathol.
Volume: 180
Pages: 1879-1896
DOI
Peer Reviewed
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