2013 Fiscal Year Final Research Report
Resolution of the signaling networks involved in the pulp cell differentiation and its clinical application
| Project/Area Number |
22390357
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAWASHIMA Nobuyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60272605)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUBE Ken-ichi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (20233760)
SAKAMOTO Kei 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00302886)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 歯髄 / 歯髄細胞 / 象牙芽細胞 / Notch / Periostin / 細胞分化 / シグナルネットワーク |
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| Research Abstract |
Losing the tooth vitality correlates to the tooth loss, this is a challenge to QOL. Strategies to keep the integrity of the pulp tissue and regenerate the new pulp tissue are hot topics. We have reported that Notch signaling is essential for differentiation of dental pulp cells. In this project, we revealed that a secretory protein, Periostin, regulated negatively the dental pulp cell differentiation into odontoblasts via notch signaling. Controlling the synthesis and production Periostin may be essential to induce the non-mineralized pulp tissue covered by the newly formed mineralized dentin.
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Research Products
(31 results)
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[Presentation] Periostin : a negative regulator of mineralization in the dental pulp tissue2013
Author(s)
Kawashima N, Mengu Z, Yamamoto M, Koizumi Y, Takimoto K, Onishi K, Suzuki N, Katsube K, Saito M, Harada H, Suda H
Organizer
16th ESE (European Society of Endodontology) Biennial Congress
Place of Presentation
Lisbon, Portugal
Year and Date
20130912-14
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[Presentation] Spheroid culture induces odonto-/osteoblastic differentiation of dental pulp cells through integrin signaling2013
Author(s)
Yamamoto M, Kawashima N, Koizumi Y, Takimoto K, Onishi K, Suzuki N, Katsube K, Saito M, Harada H, Suda H
Organizer
16th ESE
Place of Presentation
Lisbon, Portugal
Year and Date
20130912-14
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[Presentation] Mineralization of Odonotoblastic-Lineage Cells Was Accelerated by Enhanced Expression of Mef2c2011
Author(s)
N Kawashima, J Xu, N Suzuki, M Zhou, K Takimoto, Y Koizumi, M Yamamoto, S Takahashi, T Sugiyama, H Suda
Organizer
15th ESE
Place of Presentation
Cavalieri Hotel, Rome
Year and Date
20110915-17
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[Presentation] Expression of Mef2c in Murine Odontoblsts2010
Author(s)
N Kawashima, J Xu, N Suzuki, M Zhou, K Takimoto, Y Koizumi, M Yamamoto, A Salima, S Takahashi, H Suda
Organizer
8th World Endodontic Congress
Place of Presentation
Athens, Greece
Year and Date
20101006-09
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[Presentation] Wnt Signaling in Odontoblast Differentiation Induced by BMP2010
Author(s)
Y Koizumi, N Kawashima, K Takimoto, S Takahashi, J Xu, N Suzuki, M Zhou, M Yamamoto, A Salima, T Sugiyama, H Suda
Organizer
8th World Endodontic Congress
Place of Presentation
Athens, Greece
Year and Date
20101006-09
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[Presentation] Promotive effects of Sp7 on Dspp expression2010
Author(s)
N Kawashima, J Xu, T Iwata, S Takahashi, Y Koizumi, K Takimoto, Z Mengyu, C Ohi, N Suzuki, T Sugiyama, H Suda
Organizer
89th IADR General Session & Exhibition
Place of Presentation
Barcelona, Spain
Year and Date
20100714-17
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