2013 Fiscal Year Final Research Report
A multifunctional implant which can achieve the site-specific tissue regeneration
| Project/Area Number |
22390366
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MAEKAWA Kenji 岡山大学, 医歯(薬)学総合研究科, 准教授 (20304313)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 岡山大学, 大学院・自然科学研究科, 教授 (20263618)
SONOYAMA Wataru 岡山大学, 大学病院, 講師 (40325121)
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Yoshihiro 独立行政法人理化学研究所, 伊藤ナノ医工学研究所, 研究員 (40192497)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | チタン合金 / 表面改質 / アパタイト / 自己析出 / 骨結合促進 |
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| Research Abstract |
Our previous technique for apatite deposition onto the titanium surface after insertion in human body, can be only applied to the pure titanium surface. However, in order to apply this surface modification technique to clinically used implants, improvement of the technique is necessary, because all the commercially available titanium implants are made from titanium alloy. For this purpose, we developed liquid phase deposition (LPD) technique, which can induce the apatite formation onto the titanium alloy surface after insertion in human body. We found that rat bone marrow stromal cells (rBMSC) can be attached to this modified titanium alloy surface (treated by LPD technique) and the osseogenesis of rBMSC tended to be accelerated. Recently, the investigation of the bioactivity of this surface modification technique using rat model is still ongoing.
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