2013 Fiscal Year Final Research Report
Analysis of neuronal stem cell-specific expression mechanism of Fgfr3 and its function on corticogenesis
| Project/Area Number |
22500288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEUCHI Akihide 京都大学, 医学(系)研究科(研究院), 准教授 (90436618)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIWARA Masatoshi 京都大学, 大学院医学研究科, 教授
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 神経科学 / 発生・分化 / FGFR3 / 可視化 |
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| Research Abstract |
Fibroblast growth factor receptor 3 (Fgfr3) is one of the essential molecules during corticogenesis that regulates proliferation and differentiation of neuronal stem cells in mammalian brain. However, its regulatory mechanism is still largely unknown. Here we found that neuronal stem cell-specific expression of Fgr3 is achieved by (1) Fgfr3 promoter activity, and (2) utilizing mutually exclusive alternative splicing regulation of exon 9 and 10. From these analyses in alternative splicing regulators of Fgfr3, we deciphered the mechanism of mammalian corticogenesis.
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[Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene2011
Author(s)
Nishida A, Kataoka N, Takeshima Y,Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M
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Journal Title
Nat Commun
Volume: 2
Pages: 308
DOI
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