2013 Fiscal Year Final Research Report
Novel transcriptional repression mechanisms that negatively regulate neuronal differentiation
| Project/Area Number |
22500292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
KAMACHI Yusuke 大阪大学, 生命機能研究科, 准教授 (90263334)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 遺伝子 / 発生・分化 |
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| Research Abstract |
Mechanisms of how neural stem/precursor cells are established and maintained have been important questions. In this study, we investigated mechanisms of how group B1 Sox transcription factors (Sox1/2/3/19) regulate neural stem cell states using zebrafish as a model system. We show that transcriptional repressors including Zic1 and several miRNA are involved in B1 Sox-dependent-inhibition of neuronal differentiation.
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[Journal Article] An efficient binary system for gene expression in the silkworm, Bombyx mori, using GAL4 variants2011
Author(s)
Kobayashi, I., Kojima, K., Uchino, K., Sezutsu, H., Iizuka, T., Tatematsu, K., Yonemura, N., Tanaka, H., Yamakawa, M., Ogura, E., Kamachi, Y., Tamura, T.
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Journal Title
Arch. Insect. Biochem. Physiol
Volume: 76
Pages: 195-210
DOI
Peer Reviewed
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[Journal Article] The Pou5fl/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates2011
Author(s)
Iwafuchi-Doi, M., Yoshida, Y., Onichtchouk, D., Leichsenring M., Driever, W., Takemoto, T., Uchikawa, M., Kamachi, Y., Kondoh, H.
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Journal Title
Dev. Biol
Volume: 352
Pages: 354-366
DOI
Peer Reviewed
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