2013 Fiscal Year Final Research Report
Roles of the nucleus accumbens core on development of matching behavior
| Project/Area Number |
22500294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Dokkyo Medical University (2012-2013)
Fukushima Medical University (2010-2011) |
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Principal Investigator |
KAI Nobuyuki 獨協医科大学, 医学部, 助教 (50301750)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | マッチングの法則 / マッチング行動 / オペラントマッチング / 側坐核 / ラット / 交代反応 / 強化後休止 / 自発的回復 |
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| Research Abstract |
Given two options with different reinforcement rates, animals match their relative rate of responding to the relative rates of reinforcement (i.e., matching behavior). A previous study has shown that the nucleus accumbens core (AcbC) is involved in the performance of matching behavior in trained animals. However, the role of the AcbC in the acquisition of matching behavior has not been addressed. We conducted a series of experimental sessions to examine the role of the AcbC on the development of matching behavior. Lesions of the AcbC accelerated the development of matching behavior compared to the sham-operated group. The AcbC rats showed smaller probabilities of switching behavior between alternatives than shams. Our results suggest that the AcbC plays a regulatory role in the development of matching behavior through switching probabilities rather than perception of reward magnitude.
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