2012 Fiscal Year Final Research Report
Clinicopathological study of central nervous system rhabdoid tumors with or without INI1 protein expression
| Project/Area Number |
22500319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
HIRATO Junko 群馬大学, 医学部, 准教授 (60208832)
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| Co-Investigator(Kenkyū-buntansha) |
MIYANAGA Tomomi 群馬大学, 医学部, 助教 (30455951)
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| Co-Investigator(Renkei-kenkyūsha) |
NOBUSAWA Sumihito 群馬大学, 大学院・医学系研究科, 助教 (80635318)
NAKAZATO Yoichi 群馬大学, 大学院・医学系研究科, 教授 (10106908)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ラブドイド腫瘍 / INI1 蛋白 / ラブドイド細胞 / グリオーマ / epithelioid/rhabdoid cell / composite rhabdoid tumor / array CGH |
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| Research Abstract |
Central nervous system rhabdoid tumors(CNS RTs) were divided into INI1 protein-negative and -positive groups. All INI1-negative RTs were consistent with atypical teratoid rhabdoid tumor (AT/RT) in the histopathological features. Moreover, there were a few cases with combined tumors composed of INI1-positive glioma and INI1-negative rhabdoid tumors. In the INI1-positive RTs, high-grade gliomas with epithelioid/rhabdoid cells were identified, and the presence of INI1-positive AT/RT was possibly considered.
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Research Products
(11 results)
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[Journal Article] Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study2012
Author(s)
Fu YJ, Taniguchi Y, Takeuchi S, ShigaA, Okamoto K, Hirato J, Nobusawa S,Nakazato Y, Kakita A, Takahashi H.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes2012
Author(s)
Nobusawa S, Yokoo H, Hirato J, Kakita A, Takahashi H, Sugino S, Tasaki K, Itoh H, Hatori T, Shimoyama Y, Nakazawa A, Nishizawa S, Kishimoto H, Matsuoka K, Nakayama M, Okura N, Nakazato Y.
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Journal Title
Brain Pathol
Volume: 22
Pages: 689-697
DOI
Peer Reviewed
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