2012 Fiscal Year Final Research Report
analysis of synaptic transmission
| Project/Area Number |
22500333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 受容体 |
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| Research Abstract |
I identified novel mGluR-binding proteins which regulate synaptic transmission in a unique fashion. Then, I developed a high-through put analysis system for the receptorprotein interactions. Using this assay methods, I screened about 1000 drugs commonly used clinically to examine if they modulate the protein-interaction properties. I found several drugs which either enhance or diminish the interaction. The finding would be a basis of development of new therapeutics or a clue to possible sides effects of the drugs.
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