2012 Fiscal Year Final Research Report
Role of growth cone autonomy and translational trans-acting factors in axon guidance
| Project/Area Number |
22500336
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
SASAKI Yukio 横浜市立大学, 医学研究科, 特任准教授 (10295511)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
GOSHIMA Yoshio 横浜市立大学, 医学研究科, 教授 (00153750)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 分子・細胞・神経生物学 / 成長円錐 / 翻訳調節 / マイクロ RNA |
|---|
| Research Abstract |
We have investigated two mRNA-binding, translational trans-acting factors to regulate local translation in axonal growth cones in neurons. We demonstratedthat Zipcode-Binding Protein 1 (ZBP1), an mRNA-binding protein, regulates translation of β-actin mRNA, and then direction of axonal extension, via phosphorylation induced by Brain-Derived Neurotrophic Factor (BDNF). We also found that microRNAs (miRNAs), non-coding RNAs bind to mRNA, exist in growth cones. We indicate the possibility that axonal miRNAs are involved in axonal extension regulated by BDNF.
|
-
[Journal Article] Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones2013
Author(s)
Iketani M., Iizuka A., Sengoku K., Kurihara Y., Nakamura F., Sasaki Y., Sato Y., Yamane M., Matsushita M., Nairn A.C., Takamatsu K., Goshima Y., Takei K.
-
Journal Title
Dev. Neurosci
Volume: 73
Pages: 230-246
DOI
Peer Reviewed
-
-
-
-
[Journal Article] CRMP5 (Collapsin Response Mediator Protein 5) Regulates Dendritic Development and Synaptic Plasticity in the Cerebellar Purkinje Cells2011
Author(s)
Yamashita, N., Mosinger, B., Roy, A., Miyazaki, M., Ugajin, K., Nakamura, F., Sasaki, Y., Yamaguchi, K., Kolattukudy,P., Goshima, Y.
-
Journal Title
J. Neurosci
Volume: 31
Pages: 1773-1779
DOI
Peer Reviewed
-
[Journal Article] Regulation of chemotropic guidance of nerve growth cones by microRNA2011
Author(s)
Han, L., Wen, Z., Lynn, R. C., Baudet, M. L., Holt, C. E., Sasaki, Y., Bassell, G. J., Zheng, J. Q
-
Journal Title
Mol. Brain
Volume: 4
Pages: 40
DOI
Peer Reviewed
-
[Journal Article] Phosphorylation of zipcode binding protein is required for BDNF signaling of local β-actin synthesis and growth cone turning2011
Author(s)
Sasaki, Y., Welshhans, K., Wen, Z., Yao, J., Xu, M., Goshima, Y., Zheng, J. Q., Bassell, G. J.
-
Journal Title
J. Neurosci
Volume: 30
Pages: 9349-9358
DOI
Peer Reviewed
-
-
-
-
-
-
