2012 Fiscal Year Final Research Report
Functional analysis of gliotransmitters
| Project/Area Number |
22500367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | Nihon University (2011-2012)
Gunma University (2010) |
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Principal Investigator |
GOMI Hiroshi 日本大学, 生物資源科学部, 准教授 (90293240)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOHARA Shigeyoshi 理化学研究所, 脳科学総合研究センター, シニアチームリーダー (60252524)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ニューロングリア相互作用 / グリオトランスミッター |
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| Research Abstract |
We analyzed an inducible transgenic mouse model in which the expression of an inositol 1,4,5-trisphosphate absorbent “IP3-sponge” attenuated astrocytic Ca^<2+> signaling. In electron microscopy, the morphology of tripartite synapses was changed and the attenuated Ca^<2+> activity correlated with reduced astrocytic coverage of synapses in hippocampal CA1 in these animals. This finding suggests that astrocytic Ca^<2+> signaling that induces gliotransmitter secretion has a critical role in forming functional tripartite synapses.
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