2012 Fiscal Year Final Research Report
A study on the synaptic plasticity depending on sleep/wake brain state
| Project/Area Number |
22500370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUROTANI Tohru 東京大学, 大学院・総合文化研究科, 民間等共同研究員 (50195591)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 睡眠 / 覚醒 / シナプス可塑性 / 抑制性伝達 / カルシウムチャネル |
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| Research Abstract |
In the present study, we used rat brain slice preparations to investigate the sleep/wake-state dependent synaptic plasticity in inhibitory synapses in the neocortex. Pharmacological analyses, dual whole-cell recordings and non-steady state noise analyses revealed the molecular and cellular mechanisms of the state-dependent plasticity induced in inhibitory synapses at the apical dendrite and/or soma of cortical pyramidal neurons.
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