2012 Fiscal Year Final Research Report
Analysis of autoantibodies induced during progression to AIDS
| Project/Area Number |
22500387
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Kumamoto University |
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Principal Investigator |
KUWATA Takeo 熊本大学, エイズ学研究センター, 助教 (70346063)
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| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Tatsuhiko 京都大学, ウイルス研究所, 教授 (90467431)
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| Project Period (FY) |
2010 – 2012
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| Keywords | HIV / SIV / アカゲザル / エイズ / モノクローナル抗体 |
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| Research Abstract |
The role of autoantibodies in CD4+T cell depletion during HIVinfection remains unclear. In this study, many antibodies against SIV and self antigenswere isolated by phage display method. Analysis of these antibodies revealed that theinduction of autoantibdies was not due to the cross-reactivity to SIV and suggested alow cytotoxic activity of autoantibodies in SIV infection.
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