2012 Fiscal Year Final Research Report
Enhancement of the Differentiation of Cardiomyocytes from Mouse Embryonic Stem Cells and Creation of Ventricular Model based on modification of scaffold
| Project/Area Number |
22500424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Yamagata University |
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Principal Investigator |
FENG Zhonggang 山形大学, 大学院・理工学研究科, 准教授 (10332545)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takao 山形大学, 医学(系)研究科(研究院), 教授 (00142654)
UMEZU Mitsuo 早稲田大学, 理工学術院, 教授 (90132927)
KOSAWADA Tadashi 山形大学, 大学院・理工学研究科, 教授 (10143083)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞 / 組織工学 |
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| Research Abstract |
This research deals with the two critical issues for the realization of the clinical use of ES/iPS cells in the treatment of heart failure: one is the effective differentiation into cardiomyocytes from ES/iPS cells, and another is the creation of cardiac tissue equivalent. By the integration of stem cell engineering, protein engineering, and tissue engineering, a novel method for fabrication of natural-ECM included scaffold layer was developed; differentiation into cardiomyocytes was enhanced on this scaffold; and furthermore, cardiac tissue equivalent was created through stacking multi such layers. The above experiments have brought out findings in the differentiation of mouse ES cells into cardiomyocytes, in the effect of mechanical characteristics of scaffold on the differentiation, and in the construction of cardiac tissue equivalent.
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[Journal Article] Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function2012
Author(s)
I Suzuki, Y Shiraishi, S Yabe, Y Tsuboko, TK Sugai, K Matsue, T Kameyama, Y Saijo, T Tanaka, Y Okamoto, Z Feng, T Miyazaki, M Yamagishi, M Yoshizawa, M Umezu, T Yambe
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Journal Title
J of Artif Organs
Volume: 15
Pages: 49-56
Peer Reviewed
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