2012 Fiscal Year Final Research Report
The development of novel drug delivery systems based on the mechanism for intestinal absorption of botulinum toxins
| Project/Area Number |
22500427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University |
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Principal Investigator |
YAMAMOTO Yumiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403496)
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| Research Collaborator |
OGUMA Keiji 岡山大学, 大学院・医歯薬学総合研究科, 特命教授
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| Project Period (FY) |
2010 – 2012
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| Keywords | ボツリヌス毒素 / 腸管 / 薬物送達 |
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| Research Abstract |
In food-borne botulism, the orally ingested botulinum neurotoxins, which could be classified into seven types (A to G) based on their antigenicity, must be absorbed from the small intestine. In this study, we produced the liposomes modified with HA, which is a non-toxic component of the type A botulinum toxin complex, in order to develop novel intestine-targeted drug delivery systems. On the other hand, we showed that the type E botulinum toxin might bind to the intestinal cells via the Hc domain of neurotoxin.
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[Journal Article] C produced by Clostridium botulinum type C and D: comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin.2013
Author(s)
Fatmawati NN, Sakaguchi Y, Suzuki T, Oda M, Shimizu K, Yamamoto Y, Sukurai J, Matsushita O, and Oguma K.
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Journal Title
Acta Med. Okayama
Volume: 67
Pages: 9-18
Peer Reviewed
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[Journal Article] Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay.2012
Author(s)
Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamo t o Y, Neubert JK, Nolan TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, and Oguma K.
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Journal Title
J. Oral Rehabil.
Volume: 39
Pages: 63-72
Peer Reviewed
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[Journal Article] Application of purified botulinum type A neurotoxin to treat experimental trigeminal neuropathy in rats and patient with urinary incontinence and prostatic hyperplasia.2012
Author(s)
Matsuka Y, Yokoyama T, Yamamo t o Y, Suzuki T, Fatmawati NN, Nishikawa A, Ohyama T, Watanabe T, Kuboki T, Nagai A, and Oguma K.
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Journal Title
J. Toxicol
Volume: 648384
Peer Reviewed
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