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2012 Fiscal Year Final Research Report

The analysis of tissueand subtype-specificity for preventing obesity and NAFLD

Research Project

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Project/Area Number 22500689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

YAMAZAKI Tomomi  独立行政法人国立健康・栄養研究所, 栄養研究所・基礎栄養研究部, 室長 (00218439)

Project Period (FY) 2010 – 2012
Keywords生活習慣病 / 脂肪肝
Research Abstract

Saturated fatty acid-rich oil induced fatty liver in mice, and this was triggered initially by an increase in PPARγ2 protein in the liver, which led to increased expression of lipogenic genes. Inactivation of PPARγ2 may improve fatty liver induced by saturated fat. Postprandial hypertriglyceridemia in mice is induced by decreased LPL activity after fat load and is associated with obesity induced by a high-fat diet

  • Research Products

    (12 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (1 results)

  • [Journal Article] The ddY mouse: a model of postprandial hypertriglyceridemia in response to dietary fat2012

    • Author(s)
      Yamazaki T, Kishimoto K, Ezaki O
    • Journal Title

      J Lipid Res

      Volume: 53(10) Pages: 2024-2037

    • DOI

      DOI:10.1194/jlr.M023713

    • Peer Reviewed
  • [Journal Article] Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ 2 protein2012

    • Author(s)
      Yamazaki T, Kishimoto K, Miura S, Ezaki O
    • Journal Title

      J Nutr. Biochem

      Volume: 23(2) Pages: 123-132

    • DOI

      DOI:10.1016/j.jnutbio.2010.11.006

    • Peer Reviewed
  • [Journal Article] ole of DNA methylation in the regulation of lipogenicglycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012

    • Author(s)
      Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T, Miura S, Ezaki O, Suganami T, Okano M, and Ogawa Y
    • Journal Title

      Diabetes

      Volume: 61(10) Pages: 2442-2450

    • DOI

      DOI:10.2337/db11-1834

    • Peer Reviewed
  • [Journal Article] An increase in liver PPARg2 is an initial event to induce fatty liver inresponse to a diet high in butter: PPARg2 knockdown improves fatty liver induced by high-saturated fat2011

    • Author(s)
      Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O
    • Journal Title

      J Nutr. Biochem

      Volume: 22(6) Pages: 543-553

    • DOI

      DOI:10.1016/j.jnutbio.2010.04.009

    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, EzakiO, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13(3) Pages: 294-307

    • DOI

      DOI:10.1016/j.cmet.2011.01.018

    • Peer Reviewed
  • [Presentation] 大豆蛋白質β-コングリシニンの高脂肪食による脂肪肝発症予防機序2012

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都)
    • Year and Date
      2012-10-12
  • [Presentation] 魚油と大豆タンパクの体内脂肪蓄積予防機序の違い2012

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都
    • Year and Date
      2012-10-11
  • [Presentation] マウス新生仔の肝臓における脂肪合成酵素GPAT1のDNAメチル化による遺伝子発現制御2012

    • Author(s)
      江原逹弥、亀井康富、高橋真由美、袁勲梅、金井紗綾香、田村江梨奈、田中都、山崎聖美、三浦進司、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都)
    • Year and Date
      2012-10-11
  • [Presentation] マウス新生仔肝臓の脂肪合成遺伝子のDNAメチル化制御2012

    • Author(s)
      亀井康富、江原逹弥、高橋真由美、袁勲梅、金井紗綾香、山崎聖美、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-05-19
  • [Presentation] 新生仔肝臓の脂肪合成遺伝子のDNAメチル化制御2012

    • Author(s)
      亀井康富、江原逹弥、高橋真由美、袁勲梅、金井紗綾香、山崎聖美、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2012-03-25
  • [Presentation] 飽和脂肪酸過剰摂取による脂肪肝発症は肝臓PPARγ2発現ノックダウンにより予防できる2010

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋テルサ(群馬)
    • Year and Date
      2010-10-02
  • [Book] Peroxisome Proliferator-Activated Receptors(PPARs)2013

    • Author(s)
      Yamazaki T, Ezaki O
    • Total Pages
      99-116
    • Publisher
      Humana Press

URL: 

Published: 2014-08-29  

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