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2012 Fiscal Year Final Research Report

Action spectrum of the decrease of collagen flexibility caused byUV rays, and development of the new evaluation method of sunscreen

Research Project

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Project/Area Number 22500724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General human life sciences
Research InstitutionTokyo University of Technology

Principal Investigator

MAEDA Kazuhisa  東京工科大学, 応用生物学部, 教授 (50454137)

Project Period (FY) 2010 – 2012
Keywords生活素材・生活財 / 紫外線遮蔽
Research Abstract

We found that the collagen gel is exposed to UVA resulting in less elasticity. Investigations on the action spectrum of the collagen elasticity decline caused by UV rays revealed that the UV rays near 320 nm decline elasticity. Moreover, after irradiating the collagen gel with UVB+UVA2, when the fibroblast was cultured, cell survival decreased. This decrease in cell survival was rescued by irradiating the fibroblast with UVA1, and by adding catalase to the culture medium. The increase in intracellular catalase activity was considered to be one of the mechanisms in which UVA1 irradiation rescues the decrease of the cell survival on UVB+UVA2 irradiated collagen gel. It is thought that these results explain a part of the photoaging mechanism of skin caused by irradiating of UVB+UVA2 in vivo and is available as a new evaluationmethod of the sunscreen product.

  • Research Products

    (3 results)

All 2012 2011

All Presentation (3 results)

  • [Presentation] UVB曝露した培養ヒト線維芽細胞の細胞外マトリックスに対するUVA1の再構築促進効果2012

    • Author(s)
      野々口拓人、前田憲寿
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学高等教育推進機構(札幌市)
    • Year and Date
      2012-03-30
  • [Presentation] 紫外線によるコラーゲン弾力性低下の作用波長の解析とそのメカニズム2011

    • Author(s)
      前田憲寿、秋山裕昭、飯伏慶子、濱野奈々子
    • Organizer
      第11回日本抗加齢医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2011-05-28
  • [Presentation] 紫外線に引き起こされるコラーゲン弾力性低下の作用波長の解析2011

    • Author(s)
      飯伏慶子、秋山裕昭、濱野奈々子、前田憲寿
    • Organizer
      日本農芸化学会2011度大会
    • Year and Date
      2011-03-27

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Published: 2014-08-29  

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