2012 Fiscal Year Final Research Report
Identification of the genes regulate Ras-mediated signalingby cDNA expression cloning method
| Project/Area Number |
22501010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん制御遺伝子 |
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| Research Abstract |
It is important to regulate Ras-mediated signaling since constitutively active mutations of Ras genes are frequently found in various kinds of tumor cells. In this project we are aiming to identify genes with transformation suppressor activity against DT cells harboring constitutively active Ras oncogene. After a series of cDNA expression cloning around 80 candidate genes were identified.
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[Journal Article] The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.2012
Author(s)
Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H,Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M
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Journal Title
Biology Open 1:
Pages: 458-466
DOI
Peer Reviewed
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[Journal Article] A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs2010
Author(s)
Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M
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Journal Title
Oncotarget
Volume: 1
Pages: 252-64
URL
Peer Reviewed
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[Journal Article] Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice2010
Author(s)
Chandana EP, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, Kondo S, Oh J, Takahashi R, Yoshida Y, Kawashima S, Alexander DB, Kitayama H, Takahashi C, Tabata Y, Matsuzaki T, Noda M
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Journal Title
BMC Dev. Biol
Volume: 84
Pages: 84
DOI
Peer Reviewed
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