Analysis of mechanisms for immunosuppression through ILT7/NKp44/BDCA2 ligands expressed on cancer cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22501025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Keio University
• Principal Investigator: TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117)
• Co-Investigator(Kenkyū-buntansha): KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
• Project Period (FY): 2010 – 2012
• Keywords: 免疫抑制 / プラズマ細胞様樹状細胞

Research Abstract

To clarify the mechanisms of immunosuppression through ILT7/NKp44/BDCA2 ligands expressed on cancer cells, we tried to identify these ligands molecularly and successfully cloned the NKp44L. Furthermore, we showed a signal pathway, which could control the

Research Products

• [Journal Article] CCL2 is critical for immunosuppression to promote cancer metastasis. (2013)
  • Author(s): Kudo-Saito C, Shirako H, Ohike M, Tsukamoto N, Kawakami Y.
  • Journal Title: Clin Exp Metastasis Volume: 30 Pages: 393-405
  • Peer Reviewed
• [Journal Article] Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells. (2012)
  • Author(s): Yaguchi T, Goto Y, Kido K, Mochimaru H, Sakurai T, Tsukamoto N, Kudo-Saito C, Fujita T, Sumimoto H, Kawakami Y.
  • Journal Title: J Immunol. Volume: 189 Pages: 2110-2117
  • Peer Reviewed
• [Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer. (2012)
  • Author(s): Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
  • Journal Title: Cancer Sci. Volume: 103 Pages: 1617-1624
  • Peer Reviewed
• [Journal Article] Immunotherapy targeting cancer stem cells. (2012)
  • Author(s): Kawakami Y, Matsushita M, Ueda R, Tsukamoto N, Ohta S.
  • Journal Title: Nihon Rinsho Volume: 70 Pages: 2142-6
• [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies. (2011)
  • Author(s): Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y.
  • Journal Title: Int J Hematol. Volume: 93 Pages: 294-300
• [Presentation] Augmentation of anti-tumor immune responses by Kampo medicine compound which inhibits signaling associated with cancer induced immunosuppression (2012)
  • Author(s): Kamijuku H, 1 名, Tsukamoto N, 4 名,Kawakami Y.
  • Organizer: 2012 年日本免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-07
• [Presentation] Identification of human melanoma antigen with favorable characteristics for the use in immunotherapy (2012)
  • Author(s): Tsukamoto N, 3 名, Kawakami Y.
  • Organizer: 2012 年日本免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-06
• [Presentation] Roles of aryl hydrocarbon receptor (AhR) in cancer progression in tumor microenvironment (2012)
  • Author(s): Tsukamoto N, 4名, Kawakami Y.
  • Organizer: 2012年日本癌学会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2012-09-21
• [Presentation] New diagnostic and therapeutic target KU-MEL9 for chronic myeloid leukemia (CML) (2012)
  • Author(s): Matsushita M, 3 名, Tsukamoto N,Kawakami Y, 3 名.
  • Organizer: AACR Anual Meeting2012
  • Place of Presentation: Chicago USA
  • Year and Date: 2012-04-02
• [Presentation] IDO-catabolized tryptophan metabolite may be involved in the generation of immunosuppressive tumor microenvironment through induction of Treg via AhR activation (2011)
  • Author(s): Komuro M, Tsukamoto N, 1名, Kawakami Y.
  • Organizer: 2011年日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Enhanced metastasis through immunosuppressive cancer microenvironment and its control by targeting signaling molecules (2011)
  • Author(s): Kawakami Y, 2 名, Tsukamoto N, 4 名.
  • Organizer: 2011年日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] Involvement of CCL22/CCR4 in lymph node metastasis of human head and neck cancer via increasing invasion ability (2011)
  • Author(s): Tsujikawa T, 3名, Tsukamoto N, 4名,Kawakami Y.
  • Organizer: 2011年日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] がん免疫逃避機構とその制御 (2011)
  • Author(s): 河上裕, 6名, 塚本信夫
  • Organizer: 2011 年日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2011-07-01
• [Presentation] Immune escape of Snail/Slug induced EMT cancer cells through down-regulation of MICA and MICB (2010)
  • Author(s): Tsukamoto N, 3名, Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] NKp44 ligand expression on cancer cells is down-regulated by EMT (2010)
  • Author(s): Ida Y., Tsukamoto N, 6名, Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer (2010)
  • Author(s): Okabayashi K, 6名, Tsukamoto N, 4名,Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] がん免疫逃避機構とその制御 (2010)
  • Author(s): 河上裕, 2名, 塚本信夫, 4名
  • Organizer: 2010 年日本がん免疫学会
  • Place of Presentation: KKRホテル熊本
  • Year and Date: 2010-07-23
• [Patent(Industrial Property Rights)] がん免疫療法 (2012)
  • Inventor(s): 塚本信夫、松下麻衣子、服部豊、河上裕
  • Industrial Property Rights Holder: 塚本信夫、松下麻衣子、服部豊、河上裕
  • Industrial Property Number: 特願2012-132288
  • Filing Date: 2012-06-11