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2012 Fiscal Year Final Research Report

Development of the new therapeutic antibodies for mesothelioma

Research Project

  • PDF
Project/Area Number 22501026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor immunology
Research InstitutionJuntendo University

Principal Investigator

ABE Masaaki  順天堂大学, 医学部, 研究技師 (30398656)

Project Period (FY) 2010 – 2012
Keywords中皮腫 / 抗体療法 / ERC/Mesothelin / ADCC
Research Abstract

We previously developed anti-human membranous C-ERC/Mesothelin monoclonal antibody 22A31. In this study, we proved 22A31 to have anti-proliferative activity for human mesothelioma cell lines transplanted subcutaneously or intraperitonealy in mice. 22A31 was injected to mice via intratumoral or intraperitoneal routes, and it showed the inhibitory effect for the proliferation of mesothelioma cells in all experiments. Serum concentration of the secretory N-ERC/Mesothelin reflected the extent of the tumor-proliferation, and seemed to be significant in the prediction of the effect of treatment.

  • Research Products

    (2 results)

All 2013 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] NP-1250, an ABCG2 inhibitor, induces apoptotic cell death in breast carcinoma MCF7/mitoxantrone-resistant cells via a caspase-independent pathway2013

    • Author(s)
      Ito M., Kajino K., Abe M., Fujimura T., Mineki R., Ikegami T., Ishikawa T. and Hino O
    • Journal Title

      Int. J. Oncol Rep

      Volume: 29(4) Pages: 1492-1500

    • DOI

      DOI:10.3892

    • Peer Reviewed
  • [Journal Article] LRR4 and UPK3B are markers of primary mesothelial cells2011

    • Author(s)
      Kanamori-Katayama M., Kaiho A., Ishizu Y., Okamura-Oho Y., Hino O., Abe M., Kishimoto T., Sekihara H., Nakamura Y., Suzuki H., Forrest A.R.R. and Hayashizaki Y.
    • Journal Title

      PLoS One

      Volume: 6 Pages: e25391-25399

    • DOI

      DOI:10.1371

    • Peer Reviewed

URL: 

Published: 2014-08-29  

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