Pharmacogenetic analyses of a novel TC chemotherapy on ovarian and peritoneal cancers and exploration of molecular targets

2012 Fiscal Year Final Research Report

• Project/Area Number: 22501033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: Saitama Medical University
• Principal Investigator: EGUCHI Hidetaka 埼玉医科大学, 医学部, 准教授 (00260232)
• Co-Investigator(Kenkyū-buntansha): NISHIYAMA Masahiko 群馬大学, 院医学系研究科, 教授 (20198526)
• Co-Investigator(Renkei-kenkyūsha): FUJIWARA Keiichi 埼玉医科大学, 医学部, 教授 (20238629)
• Project Period (FY): 2010 – 2012
• Keywords: 薬効評価と予測 / 卵巣癌

Research Abstract

In a phase II clinical trial of weekly paclitaxel (TXL)/ IP carboplatin (CBDCA) administration on ovarian and peritoneal cancers, we determined various genetic polymorphisms and analyzed their associations with pharmacokinetics (PK) parameters of TXL at first administration and adverse effects. We found that GSTM1 deletion, ABCB1 2677G>T/A and CYP3A5 rs776746 gene polymorphisms were significantly associated with the PK parameters, appearance of grade 4 neutropenia and extent of leukopenia.

Research Products

• [Presentation] 卵巣癌/腹膜癌に対する第2相臨床試験におけるパクリタキセルのPK- PG相関解析 (2012)
  • Author(s): 岩佐紀宏、江口英孝、島田宗昭、竹内聡、藤原寛行、和田智、長尾昌二、鈴木光明、杉山徹、紀 川純三、藤原恵一、西山正彦
  • Organizer: 日本癌治療学会
  • Place of Presentation: パシフィコ横浜 神奈川県
  • Year and Date: 20121025-27
• [Presentation] PK-PG ASSOCIATION ANALYSIS OF TXL IN A PHASE II TRIAL OF WEEKLY TXL/IP CBDCA THERAPY FOR OVARIAN AND PERITONEAL CANCERS (2012)
  • Author(s): Iwasa N, Eguchi H, Shimada M, Takeuchi S, Fujiwara H, Wada S, Nagao S, Suzuki M, Sugiyama T, Kigawa J, Fujiwara K, Nishiyama M
  • Organizer: International Gynecologic Cancer Society
  • Place of Presentation: Vancouver Convention Centre,Vancouver, Canada
  • Year and Date: 20121013-16
• [Presentation] 卵巣癌/腹膜癌における週1回パクリタキセル/腹腔内カルボプラチン併用療法の第2 相試験: パクリタキ セルのゲノム薬理学的解析 (2012)
  • Author(s): 江口英孝、岩佐紀宏、島田宗昭、竹内聡、藤原寛行、和田智、長尾昌二、鈴木光明、杉山徹、紀 川純三、藤原恵一、西山正彦
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌、北海道
  • Year and Date: 20120919-21
• [Presentation] Pharmacogenetic analysis of the weekly paclitaxel/ IP carboplatin combination therapy for ovarian and peritoneal cancers (2012)
  • Author(s): Eguchi H, Iwasa N, Shimada M, Takeuchi S, Fujiwara H, Wada S, Nagao S, Suzuki M, Sugiyama T, Kigawa J, Fujiwara K,Nishiyama M
  • Organizer: American Association for Cancer Research.
  • Place of Presentation: McCormick Place West, Chicago, USA
  • Year and Date: 20120401-04