2012 Fiscal Year Final Research Report
Study of nanomaterials on chronic health effect assessment according to endpoint of carcinogenesis and lung fibrosis
| Project/Area Number |
22510035
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental impact assessment/Environmental policy
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Go 久留米大学, 医学部, 助教 (80383751)
KOYAMA Satosi 久留米大学, 医学部, 助教 (10549637)
NAKAO Motoyuki 久留米大学, 医学部, 助教 (60610566)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Toshio 東京女子医科大学, 医学部, 教授 (50120019)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | ナノマテリアル / 慢性健康影響 / 肺線維化 / 発癌 / リスク評価 |
|---|
| Research Abstract |
Experiments were conducted to evaluate properly the chronic effect of nano-materials in vivo and in vitro. Results of cytotoxicity, proliferative activity, mutagenicity and transformation were affected by the physical-chemical properties of test materials in vitro. The risk assessment at concentration of 0.1μg-1mg was performed at the single-dose of tracheal injection in normal animals, and the progress of fibrosis and oncogenesis were observed during 1.6 year in normal animals. Appropriated animal experiment was performed without using genetically modified animals. There were divergence results between in vitro and in vivo experiments.The research results should be carefully applied to human risk assessment.
|
Research Products
(6 results)
