2012 Fiscal Year Final Research Report
Search for effective constituents for life-style related diseases through expression of PPAR
| Project/Area Number |
22510240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masayuki 京都薬科大学, 薬学部, 教授 (90116129)
NAKAMURA Seikou 京都薬科大学, 薬学部, 助教 (20411035)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アーユルベヴェーダ生薬 / PPAR / メトキシフラボノール / アポルフィン型アルカロイド |
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| Research Abstract |
We mainly focused on Ayurvedic traditional medicine and have researched the active constituents for therapeutics of life-style related diseases through expression of peroxisome proliferator-activated receptor (PPAR). As the results, the extracts and the constituents from therhizomes of Kaempferia parviflora, flower of Nelumbo nucifera, and amide constituents from the fruit of Piper chaba, which are cultivated in India as well as southeast Asia, were found to show PPARγ agonist-like effects in 3T3-L1 adipocytes. The active constituents, 3,5,7,3’,4’-penta- mehoxyflavonol, N-nornuciferine, piperlonguminine, and their derivatives showed enhancement of PPARγ2, C/EBPα and β mRNA, although they had less agonistic activity at PPARγ levels. Furhermore,plasma concentrations were determined after administration of piperlonguminine and retrofractamide A in mice, together with synthesis of retrofactamide A and its derivatives to find more effectiveconstituents.
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[Presentation] メディシナルフラワー研究2013
Author(s)
松田久司,小川慶子,小神雄一郎,中村誠宏,藤本勝好,松本崇宏,吉川雅之
Organizer
ロータス(Nelumbo nucifera)花部アルカロイド成分の抗糖尿病作用
Place of Presentation
パシフィコ横浜
Year and Date
2013-03-28
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