2012 Fiscal Year Final Research Report
Discovery of novel anti-cancer drug :The search for regulatory elements of eukaryotic initiation factor 4E.
| Project/Area Number |
22550158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
TOMOO Koji 大阪薬科大学, 薬学部, 准教授 (70257898)
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| Co-Investigator(Renkei-kenkyūsha) |
IN Yasuko 大阪薬科大学, 薬学部, 准教授 (50257896)
MINOURA Katuhiko 大阪薬科大学, 薬学部, 講師 (10278591)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 翻訳開始 / 翻訳制御 / 抗ガン剤 / 結晶構造解析 / SPR / ITC / 相互作用解析 |
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| Research Abstract |
The eukaryotic initiation factor 4E(eIF4E) serves as not only a master switch of translation reaction, but also the growth of cancer cell. In this work, we have examined the interaction mode between eIF4E and 4E-binding protein (4EBP) that is endogenous regulator of eIF4E by spectroscopic analysis. We reveal that the 79PGVTS83 sequence of 4EBP plays an important role as the second binding site in the tight binding with eIF4E.
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Research Products
(5 results)
