2012 Fiscal Year Final Research Report
Multi-scale biomechanical system of blood flow in microcirculation
| Project/Area Number |
22560155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオメカニクス / 血流 / 流体力学 / 固体力学 / 計算力学 |
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| Research Abstract |
A computer simulation of transition between tumbling andtank-treading motions of a red blood cell was carried out to determine a parameter set ofcell membrane's elastic constants and natural states that can reproduce a motiontransition observed inin vitro experiments. Apparent blood flow properties depending onmechanical interaction among red blood cells were clarified for a two-branch blood vesselmodel as well as an image-based capillary network model with two dimensionalsimulations. Through these studies, quantitative data is obtained for mechanical modelingof multiscale blood flow behaviors from a red blood cell to apparent flow behaviors inmicrocirculatory system.
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