2012 Fiscal Year Final Research Report
Activation mechanism of a bacterial two-componet system by an outer membrane lipoprotein sensing cell envelope stresses
| Project/Area Number |
22570001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Saitama University |
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Principal Investigator |
HARA Hiroshi 埼玉大学, 大学院・理工学研究科, 准教授 (00173071)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Kouji 埼玉大学, 大学院・理工学研究科, 教授 (00119140)
MATSUOKA Satoshi 埼玉大学, 大学院・理工学研究科, 助教 (90509283)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 外膜リポタンパク質 / 二成分制御系 / 細胞表層ストレス |
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| Research Abstract |
The outer membrane lipoprotein RcsF is an essential component of the Rcs phosphorelay signal transduction system in Escherichia coli. It senses stresses imposed on the cell envelope and conveys the information to histidine kinase RcsC in the cytoplasmic membrane. It is suggested that RcsF functions as a ligand for RcsC in activating the system. RcsF has a region rich in proline and basic residues near the N terminus. This region is likely to play an important role in regulation of the function of RcsF in activating the Rcs system.
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