2012 Fiscal Year Final Research Report
Gonadal functions and their hormonal controls in hagfish
| Project/Area Number |
22570061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIYAMA Shunsuke 北里大学, 水産学部, 教授 (50222352)
NOZAKI Masumi 新潟大学, 自然科学系, 教授 (70136232)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 比較内分泌学 / 生理学 / 繁殖 / 進化 / ホルモン |
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| Research Abstract |
To clarify the gonadal functions of most primitive vertebrates, hagfish, we measured plasma concentrations of sex steroid, estradiol, with respect to gonadal development. In both sexes, plasma E2 showed a significant correlation with gonadal development, suggesting that estradiol is involved in the regulation of functional differentiation of gonads. We also isolated the cDNA sequence encoding cholesterol side-chain cleavage enzyme (CYP11A), which involves in the first reaction in the process of steroidogenesis. The enzyme was localized on the Leydig cells and follicle cells in testis and ovary, respectively. The CYP11A transcripts increased significantly in accordance with the developmental condition of gonads. Our findings suggest hagfish might possess similar process of sex steroidogenesis, as proposed in jawed vertebrates.
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