2012 Fiscal Year Final Research Report
Analysis of physiological regulation of tRNA from the view of its intracellular dynamics.
| Project/Area Number |
22570139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
YOSHIHISA Tohru 名古屋大学, 物質科学国際研究センター, 准教授 (60212312)
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| Project Period (FY) |
2010 – 2012
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| Keywords | tRNA / 細胞内動態 / tRNAリガーゼ / スプライシング / tRNA切断 / 出芽酵母 |
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| Research Abstract |
Recently, many researchers are interested in various regulations of tRNA function in the cytoplasm and in tRNA fragments as signaling molecules. In this project, I performed molecular genetical analyses with budding yeast as a model organism to understand relation between tRNA fragmentation in the cytoplasm and the yeast splicing system, difference in stability between mature tRNAs and introns produced by cytoplasmic splicing, and mechanism of nuclear import and export of tRNAs, which determines nuclear-cytoplasmic balance of tRNAs.
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