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2012 Fiscal Year Final Research Report

Study on NADPH oxidase function in development

Research Project

  • PDF
Project/Area Number 22570140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionKyoto Institute of Technology

Principal Investigator

KAMEI Kaeko  京都工芸繊維大学, 工芸科学研究科, 教授 (00214544)

Co-Investigator(Kenkyū-buntansha) YAMAGUCHI Masamitsu  京都工芸繊維大学, 工芸科学研究科, 教授 (00182460)
Project Period (FY) 2010 – 2012
Keywords昆虫 / ショウジョウバエ / NADPHオキシダーゼ / 活性酸素種 / 発生 / 翅形成
Research Abstract

NADPH (nicotinamide adenine dinucleotide phosphate) oxidase is an enzyme that produces reactive oxygen species. The function of NADPH oxidase in the development, especially in the wing formation, was analyzed using Drosophila. We reveled that NADPH oxidase is essential for normal wing development through the melanin formation and cross-linking of tyrosine for wing sclerotization and the suppression of apoptosis. By genetic screening, the genetic region on 3 rd chromosome that could interact with dDuox (catalytic domain of NADPH oxidase) was found.

  • Research Products

    (4 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Essential role of Duox in stabilization of Drosophila wing2011

    • Author(s)
      Nguyen Thi Tu Anh, Maiko Nishitani, Shigeharu Harada, Masamitsu Yamaguchi, and Kaeko Kamei
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286(38) Pages: 33244-33251

    • Peer Reviewed
  • [Journal Article] A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants2011

    • Author(s)
      Nguyen Thi Tu Anh, Maiko Nishitani, Shigeharu Harada, Masamitsu Yamaguchi, and Kaeko Kamei.
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 352(1-2) Pages: 91-98

    • Peer Reviewed
  • [Presentation] Essential role of Duox in stabilization of Drosophila wing.2011

    • Author(s)
      Nguyen Ti Tu Anh、西谷真依子、山口政光、亀井加恵子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-13
  • [Presentation] Role of Duox oxidase in wing development of Drosophila melanogaster2010

    • Author(s)
      Nguyen Ti Tu Anh、西谷真依子、山口政光、亀井加恵子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07

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Published: 2014-08-29  

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