2012 Fiscal Year Final Research Report
Regulation of the development of cerebral cortex by chondroitin sulfate modifying enzymes.
| Project/Area Number |
22570149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
MAEDA Nobuaki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー (90202308)
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| Co-Investigator(Kenkyū-buntansha) |
KAMIMURA Keisuke 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (30529524)
KURAOKA Mutsuki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (70569144)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖鎖生物学 / コンドロイチン硫酸 / 脳 / 硫酸転移酵素 |
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| Research Abstract |
Chondroitin sulfate proteoglycans bind with many proteins through the oversulfated structures in the chondroitin sulfate (CS) chains. In the present study, we examined the functional roles of CS oversulfated structures in the neuronal differentiation processes. The results obtained suggest that CS oversulfated structures regulate neuronal polarization by modulating neuronal cell adhesion.
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