2012 Fiscal Year Final Research Report
Bisphenol A disturbs hippocampal learning and memory system.
| Project/Area Number |
22570155
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KIMOTO Tetsuya 東京大学, 総合文化研究科, 助教 (60292843)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | ビスフェノール A / 環境ホルモン / 海馬 / 記憶学習 / 内分泌かく乱物質 / シナプス / スパイン |
|---|
| Research Abstract |
Effects of low-dose bisphenol A (BPA) on the hippocampus were examined. (1)In adult rat hippocampal slices, 10 nM BPA increased dendritic spines (especially middle-head spines with head diameter of 0.4-0.5 μm) within 2h via ERRγ localized in principal neurons. Inhibitors of MAP kinases and NMDA receptors blocked the BPA effects. (2)Perinatal exposure to low-dose BPA (30 μg/kg BW/day) via dam modulated the synapse development in the pup hippocampus. In male at postnatal8-weeks, the spine density was decreased compared with that of control. In female, perinatal BPA exposure attenuated the estrus cycle-dependent spine density changes, resulting in the disappearance of sex-related differences. (3)BPA concentration was determined in male hippocampus (approx. 64 nM) by mass-spectrometry.
|
-
-
-
-
-
[Journal Article] Hippocampal synthesis of sex steroids and corticosteroids: essential for modulation of synaptic plasticity.2011
Author(s)
Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T.
-
Journal Title
Front Neuroendocrine Sci
Volume: Article 43
DOI
Peer Reviewed
-
-
[Journal Article] Endogenous Synthesis of Corticosteroids in the Hippocampus2011
Author(s)
Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Anna B, Kimoto T, Kawato S
-
Journal Title
PLoS ONE
Volume: 6(7)
Pages: e21631
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
