2012 Fiscal Year Final Research Report
Analysis of physiological role of SVIL for cytokinesis
| Project/Area Number |
22570182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nagoya University |
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Principal Investigator |
SENGA Takeshi 名古屋大学, 医学系研究科, 准教授 (80419431)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞質分裂 |
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| Research Abstract |
We found that Supervillin (SVIL) was localized to the central spindle during cytokinesis. The localization was dependent on the phosphorylation of Ser238 of SVIL. Expression ofSVIL with the substitution of Ser238 (SVIL-S238A) to alanine inhibited progression of cytokinesis. Furthermore, aberrant ingression of cytokinetic furrow was observed in SVIL-S238A expressing cells. Our results show that phosphorylation of SVIL is essential for the completion of cytokinesis.
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