2012 Fiscal Year Final Research Report
Exploration of novel anthelmintics from rare sugars and their ester derivatives
| Project/Area Number |
22580122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
SATO Masashi 香川大学, 農学部, 教授 (20263890)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANAMI Yasuhiro 香川大学, 農学部, 教授 (30169742)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 希少糖 / 抗線虫薬 / C. elegans |
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| Research Abstract |
Rare sugars and their ester derivatives were examined for anthelmintic activity against the nematode Caenorhabditis elegans. Among the aldohexose stereoisomers, D-allose, the C3 epimer of D-glucose, inhibited the growth of C. elegans. We found that fatty acid estersof D-allose surpassed the sugar itself in anthelmintic activity. 6-O-octanoyl-D-allose showed the strongest toxicity among the fatty acid esters of D-allose.
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