2012 Fiscal Year Final Research Report
Significance of acetate metabolism in maintaining energy homeostasis during fasting
| Project/Area Number |
22580135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
FUJINO Takahiro 愛媛大学, 総合科学研究支援センター, 准教授 (40292312)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 酢酸 / 脂肪酸代謝 / ケトン体 / エネルギー代謝 |
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| Research Abstract |
The mice lacking acetyl-CoA synthetase 2 (AceCS2-KO mice) show hypothermia, hypoglycemia and decreased exercise tolerance under the prolonged fasting due to impaired utilization of acetate. We generated the mice expressing AceCS2 only in liver (mAceCS2-Liv mice). When fasted for 48hrs AceCS2-KO and mAceCS2-Liv mice resulted in fatty liver. However, feeding of chow diet containing 0.5% clofibrate for 1 week to those mice improved fatty liver under the fasting condition. In addition, hypoglycemia, hypothermia and decreased exercise tolerance were also ameliorated. These results suggest that the phenotypes such hypoglycemia, hypothermia, decreased exercise tolerance and fatty liver seen in AceCS2-KO mice under the prolonged fasting caused by impaired metabolism of free fatty aced.
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[Journal Article] Evaluating the role of rheumatoid factors in the development of rheumatoid arthritis in a mouse model with a newly established ELISA system.2010
Author(s)
Tanaka Y., Komori H., Mori S., Soga Y., Tsubaki T., Terada M.,Miyazaki T., Fujino T., Nakamura S., Kanno H., Sawasaki S., Endo Y. and Nose M.
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Journal Title
Tohoku J. Exp. Med.
Volume: 220
Pages: 199-206
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