2012 Fiscal Year Final Research Report
Effects of reactive oxygen species and lipid peroxide on antibodies production
| Project/Area Number |
22580151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu Sangyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hirofumi 北見工業大, 工学部, 准教授 (70295848)
YAMADA Koji 九州大学, 農学研究科, 教授 (60158186)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アレルギー / 活性酸素 / 脂質 / 酸化 |
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| Research Abstract |
4-hydroxy-2-nonenal, a secondary product generated bydecomposition of lipid hydroperoxides, suppressed IgA production from KHM-1B in adose-dependent manner. Tyrosine phosphorylations of signal molecules around 64 kDawere inhibited by 4-hydroxy-2-nonenal in twelve-hour culture. These data suggest that4-hudroxy-2-nonenal might facilitate allergy reaction by suppression of IgA production.
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