Critical role of hypothalamic dopamine in regulation of food intake by growing chickens on lysine-free diet

2012 Fiscal Year Final Research Report

• Project/Area Number: 22580304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Utsunomiya University
• Principal Investigator: SUGAHARA Kunio 宇都宮大学, 農学部, 教授 (50091947)
• Project Period (FY): 2010 – 2012
• Keywords: 栄養・飼養 / 摂食量 / 視床下部 / モノアミン / 脳微小透析法

Research Abstract

1.Central perfusion of L-DOPA as well as peripheral administration of lysine kept the extracellularDA level in the VMH at baseline of chickens fed on a lysine-free diet.
2. Keeping the extracellular DA level in the VMH prevents chickens on the lysine-free diet prevented from decreasing their voluntary food intake.
3. DA in the VMH plays a critical role in food intake regulation in chickens fed on a lysine-free diet.

Research Products

• [Journal Article] Oral administration of lysine restores food intake and ventromedial hypothalamic (2012)
  • Author(s): M.R. Alam , F. Yoshizawa and K. Sugahara
  • Journal Title: dopamine in chicken on a lysine-free diet British Poultry Science Volume: 53 Pages: 651-657
  • URL: http://dx.doi.org/10.1080/00071668.2012.726349
  • Peer Reviewed
• [Journal Article] Local administration of L-DOPA in the chicken ventromedial hypothalamus increases (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa, Kunio Sugahara
  • Journal Title: dopamine release in a dose-dependent manner Neuroscience Letters Volume: 529 Pages: 150-154
  • URL: http://dx.doi.org/10.1016/j.neulet.2012.08.054
  • Peer Reviewed
• [Journal Article] L-DOPA induced extracellular dopamine increases in the ventromedial hypothalamus affects food intake by chickens on a lysine-free diet (2011)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa, Kunio Sugahara
  • Journal Title: Neuroscience Letters Volume: 495 Pages: 126-129
  • URL: http://dx.doi.org/10.1016/j.neulet.2011.03.053
  • Peer Reviewed
• [Presentation] 第15回Asian-Australasian AnimalProduction Conference (タイ、バンコク) (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa and Kunio Sugahara
  • Organizer: Voluntary food intake variation in growingchickens on lysine-free diet is attributed to the plasma lysine level
  • Year and Date: 20121100
• [Presentation] 日本家禽学会2012年春季大会(名古屋) (2012)
  • Author(s): Mohammad Rashedul Alam, FumiakiYoshizawa and Kunio Sugahara
  • Organizer: Oral administration of lysine resotres food intake and ventromedial hypothalamic dopamine in chickens on a lysine-free diet
  • Year and Date: 20120300
• [Presentation] Regulation of voluntary food intake in chickens (2011)
  • Author(s): Kunio Sugahara
  • Organizer: 第9回Asian Pacific Poultry Conference(台北、台湾)招待講演
  • Year and Date: 20110300
• [Presentation] Extracellular dopamine in the ventromedial hypothalamus increases after administration of Nomifensine and L-DOPA in freely moving chicks as measured by brain microdialysis (2010)
  • Author(s): Alam M. Rashedul, Fumiaki Yoshizawa andKunio Sugahara
  • Organizer: 第21回マイクロダイアリシス研究会(東京)
  • Year and Date: 20101200
• [Presentation] Manipulation of extracellular dopamine level in the ventromedial hypothalamus affects (2010)
  • Author(s): Alam M. Rashedul, Fumiaki Yoshizawa andKunio Sugahara
  • Organizer: 第35回鳥類内分泌研究会(岡山)
  • Year and Date: 20101000
• [Book] Chapter I Neuroendocrine regulation of sedation and excitation in neonatal chicks (2013)
  • Author(s): Takashi Bungo and Kunio Sugahara
  • Total Pages: 1-28
  • Publisher: In Hormones and Behavior Ed. Davis Simonsen, Nova science publ.Inc.
• [Remarks]
  • URL: http://agri.mine.utsunomiya-u.ac.jp/hpj-deptj/anij/nutri/images/sugahara.pdf